Results 71 to 80 of about 9,203,524 (310)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Pricing Weather Derivatives [PDF]

This paper presents a general method for pricing weather derivatives. Specification tests find that a temperature series for Fresno, California follows a mean-reverting Brownian motion process with discrete jumps and ARCH errors.
Manfredo, Mark R., Richards, Timothy J., Sanders, Dwight R.   +2 more
core   +1 more source

Cool and Calm, Now Hopefully We Collect! [PDF]

, 2008
It is September 24 and thankfully no frost to speak of yet. The 2008 season will be one to look back on as a reference for variable weather effects on crops. I last posted degree day data in mid-August.
Pope, Richard O.
core   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

NEWA (Northeast Weather Association) 2004: A Year in Review [PDF]

, 2004
The Northeast Weather Association (NEWA) maintained the electronic weather network in the 2004 growing season with support from NEWA members, the NYS IPM Program, and two grants. NEWA usage continued to increase in 2004, up 16% over 2003.
Carroll, Juliet, Gibbons, John, Petzoldt, Curt, TenEyck, Cheryl, Weigle, Tim   +4 more
core  

Visualizing urban microclimate and quantifying its impact on building energy use in San Francisco [PDF]

, 2019
Weather data at nearby airports are usually used in building energy simulation to estimate energy use in buildings or evaluate building design or retrofit options.
Hong, T, Luo, X, Sun, K, Xu, Y, Zhang, W
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Degree-day-based model to predict egg hatching of Philaenus spumarius (Hemiptera: Aphrophoridae), the main vector of Xylella fastidiosa in Europe. [PDF]

Environ Entomol, 2023
Lago C, Giménez-Romero À, Morente M, Matías MA, Moreno A, Fereres A.   +5 more
europepmc   +1 more source