Results 181 to 190 of about 1,393,813 (263)

Female Mice Show Stronger Time-of-Day Modulation of Astrocytic Ca²⁺ Activity in the Sleep-Regulatory Ventrolateral Preoptic Nucleus. [PDF]

Glia
Bellier FC, Zonca L, Holcman D, Chauveau F, Rouach N, Rancillac A.   +5 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Transmission Dominance Under Random-Contact Intensification in Epidemic Networks: Multilayer Contact Network Simulation Study. [PDF]

JMIR Form Res
Zhang M, Maekawa T, Sekiguchi K, Murata T, Ohsawa Y.   +4 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Tobacco-related urinary biomarkers and lung cancer risk in women, a case-cohort analysis. [PDF]

J Natl Cancer Inst
Nalini M, O'Brien KM, Calafat AM, Wang L, Feng J, Reese CM, Xia B, Botelho JC, Wang Y, Seyler T, Roh EJ, Tashakkori NA, Blakney A, Xu K, Gail MH, Blount BC, Chang CM, Abnet CC, Sandler DP, Freedman ND, Etemadi A.   +20 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Beyond Averages: Chitosan Dispersity Affects the Bioactivity Reproducibility on In Vitro Maize (var. <i>Jubilee</i>) Germination. [PDF]

Polymers (Basel)
Giraldo JD, Peña AF, Briceño CB, Andrade-Acuña D, Aranibar L, Garrido-Miranda KA, Schoebitz M.   +6 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Adjuvant Cilostazol Therapy to Help Restore Atrioventricular Conduction in Lyme Carditis. [PDF]

JACC Case Rep
Aryal B, Mandal P, Meyer MF.
europepmc   +1 more source