Results 71 to 80 of about 1,409,799 (295)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Appendix A. Temperature data and degree days across treatments.

, 2016
Temperature data and degree days across ...
Sacha M. O'Regan (2927352), Wendy J. Palen (387292), Sean C. Anderson (228180)   +2 more
core   +1 more source

Effect of Host Plant and Temperature Regimes on the Development of Bemisia tabaci Species Complex, with Particular Emphasis on Laboratory-Estimation of the Lower Temperature Threshold and Thermal Constant [PDF]

Journal of Plant Protection and Pathology
Bemisia tabaci species complex is consisting of three closely related species with the cotton whitefly, B. tabaci considers among of the most destructive pests attacking more than 600 hosts. Although, polyphagous species can feed on a wide range of plant
I. Hemida, Dina Fathy, Marwa Ramadan, M. Bayoumy   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

WEATHER INDEX- THE BASIS OF WEATHER DERIVATIVES [PDF]

This paper approaches the subject of Weather Derivatives, more exactly their basic element the weather index. The weather index has two forms, the Heating Degree Day (HDD) and the Cooling Degree Day (CDD). We will try to explain their origin, use and the
Botos Horia Mircea, Ciumas Cristina
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Study of the Possibility of Transition to More Stringent Energy Efficiency Requirements for Translucent Structures in the Republic of Kazakhstan

Buildings
The article discusses issues related to improving the energy efficiency of translucent structures (hereinafter referred to as windows) in the construction of buildings in the Republic of Kazakhstan.
Serikbolat Yessengabulov, Meiram Kozhakhmet, Yerkebulan Zharkenov, Yeldos Abakanov, Gulzhamal Dastenova, Marzhan Nurbayeva, Aru Kozhakhmet, Meiir Zhankeldi, Assel Jexembayeva   +8 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Influence of Temperature and Photoperiod on Survival and Development of Eoreuma loftini (Lepidoptera: Crambidae)

Insects
The Mexican rice borer, Eoreuma loftini (Lepidoptera: Crambidae) is an economically important pest of sugarcane, rice, and corn in Louisiana, Texas, and Mexico. This pest is considered invasive in the US and is expanding its range northward.
James M. Villegas, Rodrigo Diaz, Michael J. Stout, Fin Papitchaya, Blake E. Wilson   +4 more
doaj   +1 more source