Results 61 to 70 of about 1,089,730 (251)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Acţiunea regulatorilor de creştere asupra rezistenței la temperaturile scăzute din perioada de înflorire, gradului de legare şi producţiei de fructe la cultura părului

Agricultural Science, 2019
The experimental plot was placed in the orchard „Terra Vitis” Ltd. founded in 2010 year. The research was conducted during the period of 2017 year. The study subject of the experience was Vystavochnaya and Noyabrskaya pear varieties, grafted on BA 29 ...
PEȘTEANU Ananie , MIHOV Dmitri , IVANOV Alexei   +2 more
doaj   +1 more source

Effect of electrochemical polishing on surface quality of nickel-titanium shape memory alloy after milling

Journal of Materials Research and Technology, 2020
Nickel-titanium shape memory alloys have been widely used in medical fields due to their unique shape memory effect, superelasticity, corrosion resistance and biocompatibility.
Guijie Wang, Zhanqiang Liu, Jintao Niu, Weimin Huang, Baolin Wang   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Graphs and networks theory [PDF]

, 2013
This chapter discusses graphs and networks ...
Estrada, Ernesto, Severini, S.
core  

Comparing the Topological and Electrical Structure of the North American Electric Power Infrastructure

, 2011
The topological (graph) structure of complex networks often provides valuable information about the performance and vulnerability of the network. However, there are multiple ways to represent a given network as a graph.
Barrows, Clayton, Blumsack, Seth, Cotilla-Sanchez, Eduardo, Hines, Paul D. H.   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Robust Grey Relational Analysis-Based Accuracy Evaluation Method

Applied Sciences
The conventional grey relational analysis (GRA) demonstrates limitations in dynamic simulation data evaluation due to its failure to simultaneously account for geometric similarity among dynamic indicators and the proximity of data curve distances.
Kang Zheng, Jie Fang, Jieqi Li, Haoran Shi, Yufan Xu, Rui Li, Ruihang Xie, Guobiao Cai   +7 more
doaj   +1 more source

Hierarchy and assortativity as new tools for affinity investigation: the case of the TBA aptamer-ligand complex

, 2017
Aptamers are single stranded DNA, RNA or peptide sequences having the ability to bind a variety of specific targets (proteins, molecules as well as ions).
Alfinito, E., Cataldo, R., Reggiani, L.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source