Results 71 to 80 of about 1,089,730 (251)

Analysis on the influencing factors of imbibition and the effect evaluation of imbibition in tight reservoirs

Petroleum Exploration and Development, 2019
To exert the imbibition between cracks and matrix effectively and enhance the development effect of tight oil reservoirs, a physical simulation method for imbibition in different scales of cores is developed by combining a high-pressure large-model ...
Zhengming YANG, Xuewei LIU, Haibo LI, Qihong LEI, Yutian LUO, Xiangyang WANG   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Effect of Flux Cored arc Welding Process Parameters on Corrosion Resistance of Austenitic Stainless Steel Claddings [PDF]

Materials Research
Cladding process can be used to create corrosion resistant surfaces from low cost materials. Austenitic stainless steel has been extensively used for weld cladding. It has excellent corrosion resistance and good weldability.
Marlon Muniz Nunes, José Henrique de Freitas Gomes, Tarcisio Gonçalves Brito, Reny Angela Renzetti   +3 more
doaj   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Morphological characterization, statistical modelling and tribological behaviour of aluminum hybrid nanocomposites reinforced with micro-nano-silicon carbide

Journal of Asian Ceramic Societies, 2019
The wear behavior of Al-10 wt. %, SiCmicro-x wt. %, SiCnano (x = 0, 1, 3, 5 and 7) hybrid nanocomposites were investigated. The effects of nano-silicon carbide (SiC) addition, the sliding distance and the applied load were studied in factorial design (5 ×
Sajjad Arif, Tanwir Alam, Akhter H. Ansari, Mohd Bilal Naim Shaikh   +3 more
doaj   +1 more source

Evaluation of effective resistances in pseudo-distance-regular resistor networks

, 2007
In Refs.[1] and [2], calculation of effective resistances on distance-regular networks was investigated, where in the first paper, the calculation was based on the stratification of the network and Stieltjes function associated with the network, whereas ...
Bailey R A, Bannai E, Chihara T S, Cycon H, Doyle P G, Haemers W H, Hislop P D, Hora A, Hora A, Hora A, Jafarizadeh M A, Jafarizadeh M A Salimi S Sufiani R, Kakutani S, Kelly F, Kemeny J G, Khinchin A Ya, Kirchhoff G, M A Jafarizadeh, Mathon R, Mehta M L, Porter C E, R Sufiani, S Jafarizadeh, Shohat J A, Tadic B Priezzhev V, van der Pol B, Wu F Y   +26 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source