Results 91 to 100 of about 3,049,614 (273)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Rao's degree sequence conjecture
Journal of Combinatorial Theory, Series B, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chudnovsky, Maria, Seymour, Paul
openaire +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Degree sequence optimization and extremal degree enumerators
Discrete Applied MathematicsThe degree sequence optimization problem is to find a subgraph of a given graph which maximizes the sum of given functions evaluated at the subgraph degrees. Here we study this problem by replacing degree sequences, via suitable nonlinear transformations, by suitable degree enumerators, and we introduce suitable degree enumerator polytopes.
openaire +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Degree-based connected graph construction with assortativity constraint
New Journal of PhysicsDegree-based graph construction is a fundamental problem in network science. A graph is simple if there are no self-loops and no multiple links between any pair of nodes in the graph. A degree sequence $d = (d_1, d_2,\cdots, d_{N})$ is graphical if d can
Yingyue Ke, Piet Van Mieghem
doaj +1 more source
, 2011 Wir betrachten zwei Probleme der algorithmischen Graphentheorie und Netzwerkanalyse. Beim "Dag Realisationsproblem" sei eine endliche Sequenz S von Paaren natürlicher Zahlen gegeben. Gibt es einen Dag (ohne parallele Kanten und Schleifen) der S als Knotengradsequenz besitzt?
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
On relationship between reformulated Sombor and other vertex--degree indices [PDF]
Transactions on CombinatoricsLet $G=(V,E)$, $V=\{v_1, v_2,\ldots,v_n\}$, $E=\{e_1, e_2,\ldots,e_m\}$, be a simple connected graph with $n\ge 2$ vertices and $m$ edges, with vertex degree sequence $\Delta=d_1\ge d_2\ge \cdots \ge d_n=\delta$, $ d_i=d(v_i)$, and edge degree sequence $\
Emina Milovanovic +4 more
doaj +1 more source
Comparing alternatives to the fixed degree sequence model for extracting the backbone of bipartite projections. [PDF]
Sci Rep, 2021 Neal ZP, Domagalski R, Sagan B.
europepmc +1 more source