Results 131 to 140 of about 9,193,291 (353)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

On neighbourhood degree sequences of complex networks [PDF]

open access: yesScientific Reports, 2019
AbstractNetwork topology is a fundamental aspect of network science that allows us to gather insights into the complicated relational architectures of the world we inhabit. We provide a first specific study of neighbourhood degree sequences in complex networks.
openaire   +7 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Extremal trees with fixed degree sequence for atom-bond connectivity index

open access: yes, 2012
The atom-bond connectivity (ABC) index of a graph G is the sum of √ d(u)+d(v)−2 d(u)d(v) over all edges uv ofG, whered(u) is the degree of vertexuinG. We characterize the extremal trees withfixed degree sequence that maximize and minimize the ABC index ...
Rundan Xing, Bo Zhou
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

On relationship between reformulated Sombor and other vertex--degree indices [PDF]

open access: yesTransactions on Combinatorics
Let $G=(V,E)$, $V=\{v_1, v_2,\ldots,v_n\}$, $E=\{e_1, e_2,\ldots,e_m\}$, be a simple connected graph with $n\ge 2$ vertices and $m$ edges, with vertex degree sequence $\Delta=d_1\ge d_2\ge \cdots \ge d_n=\delta$, $ d_i=d(v_i)$, and edge degree sequence $\
Emina Milovanovic   +4 more
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Extremal trees with fixed degree sequence for $\sigma$-irregularity [PDF]

open access: yesDiscrete Mathematics Letters, 2023
Darko Dimitrov   +3 more
doaj   +1 more source

A Review Study of Prime Period Perfect Gaussian Integer Sequences

open access: yesAxioms
Prime period sequences can serve as the fundamental tool to construct arbitrary composite period sequences. This is a review study of the prime period perfect Gaussian integer sequence (PGIS).
Ho-Hsuan Chang   +3 more
doaj   +1 more source

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