Results 131 to 140 of about 971,776 (299)
Degree sequences of random graphs
Discrete Mathematics, 1981 AbstractThe paper sets out to investigate the degree sequences d1⩾d2⩾…⩾dn of random graphs of order n in which the edges are chosen independently and with the same probability p ...
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
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On triangular biregular degree sequences
Discrete Mathematics11 pages, 1 ...
Benjamin Egan, Yuri Nikolayevsky
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Hypergraphic Degree Sequences are Hard
Bull. EATCS, 2019 We show that deciding if a given vector is the degree sequence of a 3-hypergraph is NP-complete.
Antoine Deza +3 more
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
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Majorization and the degree sequence of trees
Iberoamerican Journal of Science Measurement and CommunicationObjective. This study investigated the relation between the degree sequences of trees and the majorization order. Design/Methodology/Approach. The majorization technique was employed in accordance with the tenets of Muirhead’s theorem. Results. In this study, we proved a theorem that provides a necessary and sufficient condition for degree sequences of
Leo Egghe, Ronald Rousseau
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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On realization graphs of degree sequences
Discrete Mathematics, 2016 Given the degree sequence $d$ of a graph, the realization graph of $d$ is the graph having as its vertices the labeled realizations of $d$, with two vertices adjacent if one realization may be obtained from the other via an edge-switching operation.
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Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
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