Results 81 to 90 of about 1,107 (189)

Deguelin and Paclitaxel Loaded PEG-PCL Nano-Micelles for Suppressing the Proliferation and Inducing Apoptosis of Breast Cancer Cells

Frontiers in Bioscience-Landmark
Background: Deguelin (DGL) is a natural flavonoid reported to exhibit antitumor effects in breast cancer (BC). PEG-PCL (Polyethylene Glycol- Polycaprolactone), as polymeric micelles, has biodegradability and biocompatibility. The aim of this study was to
Yali Wang, Yang Lan, Liang Wu, Shijin Zhang, Qiang Su, Qin Yang   +5 more
doaj   +1 more source

Deguelin downregulates AKT/NFκB mediated prosurvival signals in CLL cells.

, 2016
(A) PBMCs from 3 CLL patients were treated for 24h with 0, 10, or 100 μM deguelin. Viability was evaluated by flow cytometry after Annexin V/IP staining. Figure shows immunoreactive bands for several deguelin target molecules and β-actin in western blots
Silvia Rosado (39145), Marta Morado (2622661), Juan A. Vargas-Nuñez (2622664), Nerea Rebolleda (2622655), Ignacio Losada-Fernandez (39140), Raquel Castejon (2622658), Gema Perez-Chacon (39141), Paloma Perez-Aciego (39150), Andrea Martinez (2622652), Maria Teresa Vallejo-Cremades (2622649)   +9 more
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Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2019
Exploration on anticancer candidates on inhibition of Heat Shock Protein (HSP) activity are increasing in the past ten years. Some of HSP90 inhibitor candidates were in third phase of clinical trials.
Rehmadanta Sitepu
doaj   +1 more source

Extracts from Field Margin Weeds Provide Economically Viable and Environmentally Benign Pest Control Compared to Synthetic Pesticides.

PLoS ONE, 2015
Plants with pesticidal properties have been investigated for decades as alternatives to synthetics, but most progress has been shown in the laboratory. Consequently, research on pesticidal plants is failing to address gaps in our knowledge that constrain
Prisila Mkenda, Regina Mwanauta, Philip C Stevenson, Patrick Ndakidemi, Kelvin Mtei, Steven R Belmain   +5 more
doaj   +1 more source

Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on “The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts”

Viruses, 2019
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes a lifelong persistence in the host through both chronic and latent states of infection [...]
Beatrice Mercorelli, Anna Luganini, Giorgio Palù, Giorgio Gribaudo, Arianna Loregian   +4 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis

, 2016
Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.
Ji-Hyeon Park (554738), Young-Ger Suh (1456891), Jinkyung Jung (2008810), Geumwoo Lee (2008807), Hongchan An (1456882), Sujin Lee (310412), Ho-Young Lee (1612351), Nam-Jung Kim (1480939), Sang Geon Kim (2008816), Jung Min Lee (572164), Su-Chan Lee (2008804), Seungbeom Lee (2008825), Hwayoung Yun (1507645), Ju Sung Lee (2008822), Kyu-Won Kim (43973), Young Taek Han (1456885), Jong-Ho Cha (554734), Dong-Jo Chang (2008819), Ji Won Park (285375), Jeong Hun Kim (43967), Hyun Ho Kim (1396303), Kyoung-suk Kim (2008813)   +21 more
core   +1 more source

Pharmacological inhibition of PI3K/AKT activity by deguelin to treat oral cancers

, 2007
魚藤素(deguelin)是一種非常具有發展潛力，可以抵抗癌症細胞生長的天然合成藥物。其主要機制在於抑制細胞AKT 蛋白的活性，在許多癌細胞種類中已經被證明AKT 蛋白都有過度活化的情況，如支氣管上皮細胞癌、結腸癌、急性骨髓白血病(acute myeloid leukemia，AML)、非小細胞肺癌(NSCLC)、乳癌以及皮膚鱗狀細胞(cutaneous squamous cell)，在使用魚藤素治療後具有很好的抑 癌功效。但是在口腔癌治療研究中則未被證實有任何功能以及在口腔癌中p ...
江耿男, Chiang, Geng-Nan
core  

Deguelin blocks cells survival signal pathways and induces apoptosis of HL-60 cells in vitro

, 2009
To investigate the anti-cancer effects and molecular mechanism of deguelin on the human leukemia HL-60 cells, to explore the expression and clinical significance of p-AKT, survivin and Bcl-2 in leukemia cell line HL-60 cell. Cell growth rate was assessed
Wu, Q, Chen, Y-Q, Cui, G-H, Chen, Y, Li, R   +4 more
core   +1 more source

Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-κB Signaling Pathways

, 2018
Deguelin, a rotenoid, is isolated from a natural plant species, and has biological activities including antitumor function. In the present study, we investigated the effect of deguelin on the cell adhesion, migration and invasion of NCI-H292 human lung ...
Jaw-Chyun Chen, Ming-Jen Fan, Jen-Jyh Lin, Jin-Cherng Lien, An-Cheng Huang, Yung-Ting Hsiao, Jing-Gung Chung, Rick Sai-Chuen Wu, Te-Chun Hsia   +8 more
core   +1 more source

Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.

, 2012
[[abstract]]It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family, induced cytotoxic effects through induction of cell cycle arrest and apoptosis in many types of human cancer cell lines, but deguelin-affected DNA ...
鍾景光;Chung, Jing-Gung
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