Results 91 to 100 of about 1,107 (189)

Cytotoxic effects of deguelin in cultured HNSCC cells.

open access: yes, 2013
Hep-2 cells were exposed to deguelin at a various concentration (10, 25, 50, 100 and 200 µM) for 72 hours (A) or exposed to 100 µM of deguelin for different time points (12, 24, 48 and 72 hours) (B), cell viability was then measured by MTT assay.
Chun-cheng Lu (276392)   +6 more
core   +1 more source

Schematic diagram showing possible mechanism of Deguelin action in triple negative breast cancer cells.

open access: yes, 2013
Deguelin affects EGFR/c-Met and their downstream target molecules such as p-STAT3, p-ERK, p-AKT, c-Myc and Survivin and there by affect growth/survival of breast cancer cells.
Harshadadevi Katta (419863)   +7 more
core   +1 more source

Deguelin represses both the expression of nucleophosmin and some nucleoporins: Nup88 and Nup214 in Jurkat cells

open access: yes, 2008
Since the first report about cytoplasmic nucleophosmin (NPM) in acute myelogenous leukemia with a normal karyotype was announced, the shuttling activity of NPM and its proper subcellular localization have drawn many attentions.
Wu, Q, Shu, W, Cui, G, Chen, Y, Li, R
core   +1 more source

Total Synthesis of dl-Deguelin

open access: yesAgricultural and Biological Chemistry, 1960
FUKAMI, Hiroshi   +3 more
openaire   +3 more sources

Supplementary Table 1 from A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy

open access: yes, 2008
Supplementary Table 1 from A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and ...
Gordon Mills (499661)   +13 more
core   +1 more source

Deguelin induces cellular ceramide synthesis.

open access: yes, 2013
Hep-2 cells were exposed to 100 µM of deguelin with or without fumonisin B1 (20 µM) for indicated time points, intracellular ceramide level was analyzed using methods mentioned above (A). Hep-2 cells were treated with fumonisin B1 (20 µM) or C6-ceramide (
Chun-cheng Lu (276392)   +6 more
core   +1 more source

Concise Synthesis of the Chemopreventitive Agent (±)-Deguelin via a Key 6-Endo Hydroarylation

open access: yes, 2016
A concise total synthesis of (±)-deguelin was achieved with a longest linear sequence of six steps in 68% yield.
Dalibor Sames (1432975)   +1 more
core   +1 more source

Deguelin gavage is well tolerated.

open access: yes, 2013
Bodyweight is determined before and after Deguelin treatment. The gain in bodyweight is a sign for good tolerance of the substance. The graph represents the increases in bodyweight vs. weight at begin of the experiment.
Bertram Scheller (318724)   +8 more
core   +1 more source

Correction: A Novel Derivative of Deguelin [PDF]

open access: yesCancer Prevention Research, 2009
openaire   +1 more source

Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro

open access: yes, 2007
OBJECTIVE: To investigate antitumor activity and molecular mechanism of deguelin to the human U937 leukaemia cells and to explore the mechanisms regulating cell cycle and nucleoporin 98 (Nup98) and nucleoporin 88 (Nup88) in vitro. METHODS: The effects of
Chen, WH   +5 more
core  

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