A Highly Reproducible Rotenone Model of Parkinson's Disease
Neurobiology of Disease, 2009 The systemic rotenone model of Parkinson's disease (PD) accurately replicates many aspects of the pathology of human PD and has provided insights into the pathogenesis of PD.
Víctor Tapias +2 more
exaly +3 more sources
Rotenone causes mitochondrial dysfunction and prevents maturation in porcine oocytes
PLoS ONE, 2022 Rotenone is a commonly used insecticidal chemical in agriculture and it is an inhibitor of mitochondrial complex Ⅰ. Previous studies have found that rotenone induces the production of reactive oxygen species (ROS) by inhibiting electron transport in the ...
Geun Heo +7 more
doaj +2 more sources
The effect of resveratrol on changes of oxidative stress factors induced by rotenone in hippocampus of ovariectomized rats [PDF]
Fiyz̤, 2023 Background: Rotenone as a pesticide, damages the nervous system by oxidative stress. According to the published articles that reported the protective role of estrogen in the nervous system and resveratrol against oxidative stress, in this study, the ...
Mahboobeh Aghagolzadeh +3 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 Microglia-mediated chronic neuroinflammation has been associated with cognitive decline induced by rotenone, a well-known neurotoxic pesticide used in agriculture. However, the mechanisms remain unclear.
Qinghui Wang +12 more
doaj +1 more source
Transduction of yeast NDI1 gene reduces the damages demonstrated by a rotenone-induced differentiated Parkinson's disease cell model [PDF]
Jichu yixue yu linchuang, 2023 Objective To provide a basis for gene therapy of sporadic Parkinson's disease (PD) caused by mitochondrial complex Ⅰ dysfunction, yeast complex Ⅰ (expressed by internal NADH dehydrogenase,NDI1) was tested to replace human complex Ⅰ with functional ...
SHEN Luxi, XU Xuejing, YE Yifan, CHEN Zhuo, CHEN Lan, SHEN Yuqi, LI Hongzhi
doaj +1 more source
Rotenone Decreases Hatching Success in Brine Shrimp Embryos by Blocking Development: Implications for Zooplankton Egg Banks. [PDF]
PLoS ONE, 2016 While many zooplankton species recover quickly after the treatment of water resources with the piscicide, rotenone, some fail to reach pretreatment population density or, in rare cases, do not reappear at all.
Joseph A Covi +3 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 Rotenone, an insecticide that inhibits mitochondrial complex I and generates oxidative stress, is responsible for neurological disorders and affects the female reproductive system. However, the underlying mechanism is not fully understood.
Xiaofei Wang +7 more
doaj +1 more source
Glial cells modulate retinal cell survival in rotenone-induced neural degeneration
Scientific Reports, 2021 Administration of the mitochondrial complex I inhibitor rotenone provides an excellent model to study the pathomechanism of oxidative stress-related neural degeneration diseases.
Hiroshi Tawarayama +3 more
doaj +1 more source
Screening the excellent species of genus Derris and studies on its induction and cultivation
Guangxi Zhiwu, 2023 Derris Lour., widely distributed in Southwest China, has promising development and utilization values as a raw material source of biopesticide rotenone.
Yanlin PAN +5 more
doaj +1 more source
Unexpected improvements of spatial learning and memory abilities in chronic rotenone intoxicated mice. [PDF]
PLoS ONE, 2014 The liposoluble insecticide rotenone is commonly used as a mitochondrial complex I inhibitor to replicate Parkinson's disease (PD) pathological features.
Fengju Jia +4 more
doaj +1 more source