Results 31 to 40 of about 43,287 (200)

Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats

Behavioral and Brain Functions, 2020
Background Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions, and cognition.
Dina M. Monir, Motamed E. Mahmoud, Omyma G. Ahmed, Ibrahim F. Rehan, Amany Abdelrahman   +4 more
doaj   +1 more source

Spirulina Ameliorates Oxidative Damage and Inflammation in Rotenone-Induced Neurotoxicity in Male Mice

International Journal of Medical Toxicology and Forensic Medicine, 2022
Background: Rotenone, a chemical compound produced naturally by leguminous plants, has conventionally been used as a pesticide by blocking the uptake of oxygen by body cells.
Marwa E.A. EL- Shamarka , Ahmed M.S. Hussein , Ola N. Sayed, Eman S Said, Marwa A Mwaheb   +4 more
doaj  

Effects of Enteric Environmental Modification by Coffee Components on Neurodegeneration in Rotenone-Treated Mice

Cells, 2019
Epidemiological studies have shown that coffee consumption decreases the risk of Parkinson’s disease (PD). Caffeic acid (CA) and chlorogenic acid (CGA) are coffee components that have antioxidative properties.
Ikuko Miyazaki, Nami Isooka, Kouichi Wada, Ryo Kikuoka, Yoshihisa Kitamura, Masato Asanuma   +5 more
doaj   +1 more source

Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases. [PDF]

PLoS ONE, 2012
The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT) has been linked to Parkinson disease (PD) etiology and is often used to model this neurodegenerative disease (ND).
Yofre Cabeza-Arvelaiz, Robert H Schiestl
doaj   +1 more source

Neurodegeneration induced by rotenone exposure in BY200 worms.

, 2023
A. Example images and detection of (i) control, (ii) 0.03 μm rotenone exposed, and (iii) 0.5 μM rotenone exposed worms (scale bar = 10 μm). Each dendrite is labeled as a star, square, triangle, or circle. N = 1 represents a single dendrite. B-E. Selected
Joel Meyer (429955), Zachary Kalmanson (16510499), Jessica Hartman (57940), Andrew S. Clark (16510496), Adriana San-Miguel (2052883), Katherine Morton (3776974)   +5 more
core   +1 more source

Magnolol as a Protective Antioxidant Alleviates Rotenone-Induced Oxidative Stress and Liver Damage through MAPK/mTOR/Nrf2 in Broilers

Metabolites, 2023
This study aimed to investigate the protective effects and molecular mechanism of magnolol supplementation on rotenone-induced oxidative stress in broilers. Two hundred and eighty-eight old male AA broilers were randomly divided into four groups: the CON
Weishi Peng, Nanxuan Zhou, Zehe Song, Haihan Zhang, Xi He   +4 more
doaj   +1 more source

Effects of Low Concentrations of Rotenone Upon Mitohormesis in SH-SY5Y Cells

Dose-Response, 2013
The mitochondrial toxin rotenone exerts cytotoxicity via overproduction of reactive oxygen species (ROS) and depolarization of the mitochondrial membrane.
Xiong Yuyun, Qian Jinjun, Xu Minfang, Qiu Jing, Xia Juan, Ma Rui, Zhu Li, Gao Jing   +7 more
doaj   +1 more source

New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/MT-ND4 Mutation Associated with Leber’s Hereditary Optic Neuropathy

Molecules, 2022
The finding that the most common mitochondrial DNA mutation m.11778G>A/MT-ND4 (p.R340H) associated with Leber’s hereditary optic neuropathy (LHON) induces rotenone resistance has produced a long-standing debate, because it contrasts structural evidence ...
Francesco Musiani, Laura Rigobello, Luisa Iommarini, Valerio Carelli, Mauro Degli Esposti, Anna Maria Ghelli   +5 more
doaj   +1 more source

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells

Frontiers in Molecular Neuroscience, 2021
Nedd4 family interacting protein 1 (Ndfip1) is an adaptor of Nedd4-family ubiquitin ligases. Experimental results showed that Ndfip1 had a potential neuroprotective effect in neurology diseases.
Xin Liu, Le Qu, Le Qu, Na Zhang, Na Zhang, Xiaoqi Yu, Xiaoqi Yu, Zhixin Xiao, Limei Song, Junxia Xie, Junxia Xie, Huamin Xu, Huamin Xu   +12 more
doaj   +1 more source

As alterações gastrointestinais e olfatórias precedem os sinais motores no modelo experimental da doença de Parkinson induzido pela rotenona [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia, Florianópolis, 2013Existem hipóteses que o processo patológico da Doença de Parkinson inicia-se no Sistema Nervoso ...
Morais, Lívia Hecke
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