Results 31 to 40 of about 48,544 (194)

Forced exercise activates the NrF2 pathway in the striatum and ameliorates motor and behavioral manifestations of Parkinson's disease in rotenone-treated rats

Behavioral and Brain Functions, 2020
Background Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions, and cognition.
Dina M. Monir, Motamed E. Mahmoud, Omyma G. Ahmed, Ibrahim F. Rehan, Amany Abdelrahman   +4 more
doaj   +1 more source

Effects of Enteric Environmental Modification by Coffee Components on Neurodegeneration in Rotenone-Treated Mice

Cells, 2019
Epidemiological studies have shown that coffee consumption decreases the risk of Parkinson’s disease (PD). Caffeic acid (CA) and chlorogenic acid (CGA) are coffee components that have antioxidative properties.
Ikuko Miyazaki, Nami Isooka, Kouichi Wada, Ryo Kikuoka, Yoshihisa Kitamura, Masato Asanuma   +5 more
doaj   +1 more source

Synthesis and bioactivity of rotenone oxime O-ether derivatives [PDF]

, 2012
A series of rotenone oxime O-ether derivatives were synthesized and characterized. All compounds were tested for their insecticidal, miticidal and fungicidal activities against the selected pests and compared with those of rotenone.
Wang, Y, Zhou, Z, Cao, G
core   +1 more source

Rotenone Neurotoxicity Causes Dopamine Neuron Loss in Zebrafish

University of Ottawa Journal of Medicine, 2015
: Objectives: We sought to determine whether rotenone, a commonly used pesticide, exhibits neurotoxicity in zebrafish by causing dopamine neuron loss through rotenone-induced oxidative damage.
Simon Martel, Jonathan Y Keow, Marc Ekker   +2 more
doaj   +1 more source

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells

Frontiers in Molecular Neuroscience, 2021
Nedd4 family interacting protein 1 (Ndfip1) is an adaptor of Nedd4-family ubiquitin ligases. Experimental results showed that Ndfip1 had a potential neuroprotective effect in neurology diseases.
Xin Liu, Le Qu, Le Qu, Na Zhang, Na Zhang, Xiaoqi Yu, Xiaoqi Yu, Zhixin Xiao, Limei Song, Junxia Xie, Junxia Xie, Huamin Xu, Huamin Xu   +12 more
doaj   +1 more source

Remaining neurodegeneration metrics for the rotenone exposure.

, 2023
Remaining neurodegeneration metrics for the rotenone exposure.
Joel Meyer (429955), Zachary Kalmanson (16510499), Jessica Hartman (57940), Andrew S. Clark (16510496), Adriana San-Miguel (2052883), Katherine Morton (3776974)   +5 more
core   +1 more source

Magnolol as a Protective Antioxidant Alleviates Rotenone-Induced Oxidative Stress and Liver Damage through MAPK/mTOR/Nrf2 in Broilers

Metabolites, 2023
This study aimed to investigate the protective effects and molecular mechanism of magnolol supplementation on rotenone-induced oxidative stress in broilers. Two hundred and eighty-eight old male AA broilers were randomly divided into four groups: the CON
Weishi Peng, Nanxuan Zhou, Zehe Song, Haihan Zhang, Xi He   +4 more
doaj   +1 more source

Pramipexole protective effect on rotenone induced neurotoxicity in mice [PDF]

, 2011
Introduction: Pramipexole is a new dopaminergic drug which has been approved for PD treatment. However, we tried to find a new capacity for this drug rather than symptomatic effect. Materials and Methods: A chronic
Mohamed M. Salama, Dina El-Tantawy, Sahar A. El-Dakroury, Hasan Abd-Elghaffar, Sara El-Dosouky, Abdelaziz A. Ghanem, Seham A. Gad-Elhak   +6 more
core  

Rotenone-induced mitochondrial complex I inhibition promotes lipid peroxidation in BeWo trophoblast cells.

, 2020
Panel A: Five major protein bands with molecular weights of approximately 90, 70, 50, 45, and 35 kDa showed immunoreactivity for 4-HNE modifications in control and treated trophoblast cells from whole cell lysates.
O’Llenecia S. Walker (8486163), Michael K. Wong (646399), Mohamed Adam (529112), Sandeep Raha (177509), Rehginald Ragos (8486166), Anson Cheung (8486169)   +5 more
core   +1 more source

Neuroprotective effect of butin against rotenone-induced Parkinson’s disease mediated by antioxidant and anti-inflammatory actions through paraoxonase-1-induction

Journal of Taibah University for Science, 2022
This investigation aimed to assess the anti-Parkinson's effect of butin in rotenone-treated rats. A total of 24 albino Wistar rats were segregated into four groups equally as follows: Group I (normal) and Group II (rotenone control); Group III and Group ...
Fahad A. Al-Abbasi
doaj   +1 more source