Results 51 to 60 of about 48,544 (194)
As alterações gastrointestinais e olfatórias precedem os sinais motores no modelo experimental da doença de Parkinson induzido pela rotenona [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia, Florianópolis, 2013Existem hipóteses que o processo patológico da Doença de Parkinson inicia-se no Sistema Nervoso ...
Morais, Lívia Hecke
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Regulation of respiration in rotenone-treated tobacco cell suspension cultures
, 2001 The original publication can be found at www.springerlink.comCells of Nicotiana tabacum L. suspension cultures were treated with the respiratory inhibitor rotenone, which specifically inhibits complex I activity of mitochondria.
Wiskich, J., Soole, K., Zhang, Q.
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Neurobiology of Disease, 2014 Parkinson's disease (PD), caused by selective loss of dopaminergic (DA) neurons in the substantia nigra, is the most common movement disorder with no cure or effective treatment.
Ran-Der Hwang +8 more
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Frontiers in Neuroscience, 2020 Astrocytes can protect neurons against oxidative stress and excitability-dependent disorders, such as epilepsy. Valeriana officinalis has been used as anticonvulsant and can exert an antioxidant effect, which may underlie its opposing action against the ...
Ana Paula Amaral de Brito +3 more
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Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility
Scientific Reports, 2023 Respiratory complex I is a major cellular energy transducer located in the inner mitochondrial membrane. Its inhibition by rotenone, a natural isoflavonoid, has been used for centuries by indigenous peoples to aid in fishing and, more recently, as a ...
Caroline S. Pereira +4 more
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, 1950 The Goodhue method is adapted to estimate rotenone in concentrations varying between 0.01 and 0.10 mg./c.c. The influence of spray auxiliaries and of dehydrorotenone, the primary decomposition product of rotenone, has been investigated.
Pollard, A. G., Subba Rao, N. V.
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Pyrrolidine dithiocarbamate ameliorates rotenone-induced Parkinson’s disease in rats
Bulletin of Faculty of Pharmacy Cairo University, 2017 Pyrrolidine dithiocarbamate (PDTC), a low-molecular-weight thiol antioxidant, possesses neuroprotection; however, its possible modulatory effect in Parkinson’s disease (PD) has not been tested.
Noha F. Abdelkader +4 more
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The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells [PDF]
, 2005 Deficiencies in Complex I have been observed in Parkinson's disease (PD) patients. Systemic exposure to rotenone, a Complex I inhibitor, has been shown to lead to selective dopaminergic cell death in vivo and toxicity in many in vitro models, including ...
Hastings, TG +5 more
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Mechanism of Toxicity in Rotenone Models of Parkinson's Disease
, 2003 Exposure of rats to the pesticide and complex I inhibitor rotenone reproduces features of Parkinson's disease, including selective nigrostriatal dopaminergic degeneration and α-synuclein-positive cytoplasmic inclusions (Betarbet et al., 2000; Sherer et ...
J. Timothy Greenamyre +9 more
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Journal of Neuroinflammation, 2021 Background Cognitive decline occurs frequently in Parkinson’s disease (PD), which greatly decreases the quality of life of patients. However, the mechanisms remain to be investigated.
Dongdong Zhang +9 more
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