Results 61 to 70 of about 43,287 (200)
Rotenone induced microglial activation via p38 MAPK.
, 2013 (A) BV2 cells were treated with different doses of rotenone for 6 hours or 1 µg/mL LPS for 1 hour and lysed in lysis buffer. The lysates were immunoblotted with the indicated antibodies. (B) Quantitative analysis of the data from (A), showing the density
Feng Gao (3548) +3 more
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Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
Frontiers in Molecular Neuroscience, 2020 Parkinson’s disease (PD) is a neurodegenerative disorder, and the hallmarks of this disease include iron deposition and α-synuclein (α-syn) aggregation. Hepcidin could reduce iron in the central and peripheral nervous systems.
Meiqi Li +5 more
doaj +1 more source
Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein
Neural Regeneration Research, 2018 Genistein, a potent antioxidant compound, protects dopaminergic neurons in a mouse model of Parkinson's disease. However, the mechanism underlying this action remains unknown.
Huan-Cheng Wu +9 more
doaj +1 more source
Rotenone-Induced Optic Nerve Damage and Retinal Ganglion Cell Loss in Rats
BiomoleculesRotenone is a mitochondrial complex I inhibitor that causes retinal degeneration. A study of a rat model of rotenone-induced retinal degeneration suggested that this model is caused by indirect postsynaptic N-methyl-D-aspartate (NMDA) stimulation ...
Yasuko Yamamoto +2 more
doaj +1 more source
Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy
, 2020 Neuroinflammation is a feature common to neurodegenerative diseases, such as Parkinson’s disease (PD), which might be responsive to therapeutic intervention. Rotenone has been widely used to establish PD models by inducing mitochondrial dysfunction
Fei Ding +6 more
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Regulation of respiration in rotenone-treated tobacco cell suspension cultures
, 2001 The original publication can be found at www.springerlink.comCells of Nicotiana tabacum L. suspension cultures were treated with the respiratory inhibitor rotenone, which specifically inhibits complex I activity of mitochondria.
Wiskich, J., Soole, K., Zhang, Q.
core +1 more source
Cells, 2018 Current treatments for Parkinson’s disease (PD) only alleviate symptoms doing little to inhibit the onset and progression of the disease, thus we must research the mechanism of Parkinson’s.
Ethan Chernivec +2 more
doaj +1 more source
Betaine Protects Against Rotenone-Induced Neurotoxicity in PC12 Cells
, 2013 Rotenone is an inhibitor of mitochondrial complex I-induced neurotoxicity in PC12 cells and has been widely studied to elucidate the pathogenesis of Parkinson's disease.
Kim, Yun Hee +8 more
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Biophysical Characterization of α-Synuclein and Rotenone Interaction [PDF]
, 2013 Previous studies revealed that pesticides interact with α-synuclein and accelerate the rate of fibrillation. These results are consistent with the prevailing hypothesis that the direct interaction of α-synuclein with pesticides is one of many suspected ...
Einarsdóttir, Ólöf +12 more
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, 2015 Xijin Wang,1 Qiang Guan,2 Meihua Wang,1 Liu Yang,1 Jie Bai,1 Zhiqiang Yan,3 Yuhong Zhang,4 Zhenguo Liu11Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 2Department of Neurology, Tongji Hospital ...
Wang M +7 more
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