Results 61 to 70 of about 48,544 (194)

Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells

, 2019
Rotenone exposure has emerged as an environmental risk factor for inflammation-associated neurodegenerative diseases. However, the underlying mechanisms responsible for the harmful effects of rotenone in the brain remain poorly understood.
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Effects of chronic low dose rotenone treatment on human microglial cells

Molecular Neurodegeneration, 2009
Background Exposure to toxins/chemicals is considered to be a significant risk factor in the pathogenesis of Parkinson's disease (PD); one putative chemical is the naturally occurring herbicide rotenone that is now used widely in establishing PD models ...
Nicholson Louise FB, Shaikh Shamim B
doaj   +1 more source

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells

Frontiers in Molecular Neuroscience, 2020
Parkinson’s disease (PD) is a neurodegenerative disorder, and the hallmarks of this disease include iron deposition and α-synuclein (α-syn) aggregation. Hepcidin could reduce iron in the central and peripheral nervous systems.
Meiqi Li, Jianan Hu, Xiaoyu Yuan, Lihua Shen, Li Zhu, Qianqian Luo   +5 more
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Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases.

PLoS ONE, 2012
The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT) has been linked to Parkinson disease (PD) etiology and is often used to model this neurodegenerative disease (ND).
Yofre Cabeza-Arvelaiz, Robert H Schiestl
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Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7

, 2015
Xijin Wang,1 Qiang Guan,2 Meihua Wang,1 Liu Yang,1 Jie Bai,1 Zhiqiang Yan,3 Yuhong Zhang,4 Zhenguo Liu11Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 2Department of Neurology, Tongji Hospital ...
Wang M, Liu Z, Yan Z, Yang L, Zhang Y, Guan Q, Wang X, Bai J   +7 more
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Essential Roles of Caspases and Their Upstream Regulators in Rotenone- Induced Apoptosis

, 2008
In the present study, we examined whether caspases and their upstream regulators are involved in rotenone-induced cytotoxicity. Rotenone significantly inhibited the proliferation of oral cancer cell lines in a dose-dependent manner compared to normal ...
李繼忠;黃明賢;楊毅奇;賴宗慶;龐飛;蕭宏昇;郭彥彬, LEE, JIH-JONG;HUANG, MING-SHYAN;YANG, I -CHI;LAI, TSUNG-CHING;PANG, FEI VICTOR;HSIAO, MICHAEL;KUO, MARK YEN-PING, Jui-Ling Wang, Tsung-Ching Lai, I-Chi Yang, Mark Y.P. Kuo, Victor Fei Pang, Michael Hsiao, Jihjong Lee, Lee, J.; Huang, M.S.; Yang, I.C.; Lai, T.C.; Wang, J.L.; Pang, V.F.; Hsiao, M.; Kuo, M.Y., Ming-Shyan Huang   +10 more
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Neurochemical and Behavior Deficits in Rats with Iron and Rotenone Co-treatment: Role of Redox Imbalance and Neuroprotection by Biochanin A

Frontiers in Neuroscience, 2017
Increasing evidences show that the etiology of Parkinson's disease (PD) is multifactorial. Studying the combined effect of several factors is becoming a hot topic in PD research.
Lijia Yu, Xijin Wang, Hanqing Chen, Zhiqiang Yan, Meihua Wang, Yunhong Li   +5 more
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Chronic exposure to rotenone increases cellular oxidative stress.

, 2012
SK-N-MC cells were cultured in the absence or presence of a marginally toxic (5 nM) or a moderately toxic dose (50 nM) of rotenone for 4 weeks. Results are shown as the mean ± SEM, determined for each treatment group in 3 independent experiments ...
Robert H. Schiestl (1632), Yofre Cabeza-Arvelaiz (138946)   +1 more
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Beef heart mitochondria for the Rotenone monitoring. [PDF]

, 2010
A new procedure for the selective monitoring of the Rotenone is proposed. Since the Rotenone inhibits the first site of the mitochondrial respiratory chain in all living organisms, the proposed method is based on measurements of inhibition of the ...
M. Bragadin, F. Cima, BRAGADIN, Marcantonio, DE PIERI S, MANENTE, Sabrina, L. Ballarin, CIMA, FRANCESCA, S. Manente, MANE E, CAPODAGLIO, Gabriele, CAPODAGLIO G, BRAGADIN M., A. Iero, S. De Pieri, BALLARIN, LORIANO, E. Mane E, DE PIERI, SILVIA, G. Capodaglio, IERO A, MANENTE S   +19 more
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Rotenone, Paraquat, and Parkinson’s Disease

Environmental Health Perspectives, 2011
Abstract Background Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson’s disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans.
Tanner, Caroline M., Kamel, Freya, Ross, G. Webster, Hoppin, Jane A., Goldman, Samuel M., Korell, Monica, Marras, Connie, Bhudhikanok, Grace S., Kasten, Meike, Chade, Anabel R., Comyns, Kathleen, Richards, Marie Barber, Meng, Cheryl, Priestley, Benjamin, Fernandez, Hubert H., Cambi, Franca, Umbach, David M., Blair, Aaron, Sandler, Dale P., Langston, J. William   +19 more
openaire   +2 more sources