Results 101 to 110 of about 1,094 (190)

Schematic diagram showing possible mechanism of Deguelin action in triple negative breast cancer cells.

, 2013
Deguelin affects EGFR/c-Met and their downstream target molecules such as p-STAT3, p-ERK, p-AKT, c-Myc and Survivin and there by affect growth/survival of breast cancer cells.
Harshadadevi Katta (419863), Rutulkumar Patel (419864), Xinjian Peng (357087), Miguel Muzzio (419865), Genoveva Murillo (357089), Rajeshwari Mehta (419862), Fatouma Alimirah (357086), Rajendra G. Mehta (357090)   +7 more
core   +1 more source

Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.

, 2012
[[abstract]]It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family, induced cytotoxic effects through induction of cell cycle arrest and apoptosis in many types of human cancer cell lines, but deguelin-affected DNA ...
鍾景光;Chung, Jing-Gung
core  

Total Synthesis of dl-Deguelin

Agricultural and Biological Chemistry, 1960
FUKAMI, Hiroshi, ODA, Junichi, SAKATA, Genzo, NAKAJIMA, Minoru   +3 more
openaire   +3 more sources

Design, Synthesis, and Biological Evaluation of Novel Deguelin-Based Heat Shock Protein 90 (HSP90) Inhibitors Targeting Proliferation and Angiogenesis

, 2016
Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.
Ji-Hyeon Park (554738), Young-Ger Suh (1456891), Jinkyung Jung (2008810), Geumwoo Lee (2008807), Hongchan An (1456882), Sujin Lee (310412), Ho-Young Lee (1612351), Nam-Jung Kim (1480939), Sang Geon Kim (2008816), Jung Min Lee (572164), Su-Chan Lee (2008804), Seungbeom Lee (2008825), Hwayoung Yun (1507645), Ju Sung Lee (2008822), Kyu-Won Kim (43973), Young Taek Han (1456885), Jong-Ho Cha (554734), Dong-Jo Chang (2008819), Ji Won Park (285375), Jeong Hun Kim (43967), Hyun Ho Kim (1396303), Kyoung-suk Kim (2008813)   +21 more
core   +1 more source

Deguelin induces cytotoxicity dependent on dose in primary CLL cells.

, 2016
PBMCs from CLL patients (n = 35) and healthy donors (n = 10) were incubated with or without deguelin for 48 h. Apoptosis was evaluated by flow cytometry after double staining with Annexin V-FITC and PI and it is expressed as a percentage relative to a ...
Silvia Rosado (39145), Marta Morado (2622661), Juan A. Vargas-Nuñez (2622664), Nerea Rebolleda (2622655), Ignacio Losada-Fernandez (39140), Raquel Castejon (2622658), Gema Perez-Chacon (39141), Paloma Perez-Aciego (39150), Andrea Martinez (2622652), Maria Teresa Vallejo-Cremades (2622649)   +9 more
core   +1 more source

Effect on proliferation and apoptosis in RPM1-8226 human myeloma cells and regulation on steroid receptor coactivator-3 by deguelin

, 2009
Objective: To investigate the effects of deguelin on the proliferation inhibition and apoptosis induction in RPMI-8226 cells in vitro, as well as the regulation of steroid receptor coactivator-3 (SRC-3) to explore the relationship between them.
Shu, W-X, Chen, Y, Li, R
core  

DEGUELIN AS A THERAPEUTIC DRUG FOR TRIPLE NEGATIVE AND METASTATIC BREAST CANCER

, 2011
Breast cancer is a second leading cause of cancer related deaths. 15-20 % of women with Breast cancer are diagnosed with Triple negative breast cancer (ER, PR, and HER2 –ve) which is the most aggressive type showing higher incidence of recurrence at the ...
Kalra, Amit
core  

Correction: A Novel Derivative of Deguelin [PDF]

Cancer Prevention Research, 2009
openaire   +1 more source

Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro

, 2007
OBJECTIVE: To investigate antitumor activity and molecular mechanism of deguelin to the human U937 leukaemia cells and to explore the mechanisms regulating cell cycle and nucleoporin 98 (Nup98) and nucleoporin 88 (Nup88) in vitro. METHODS: The effects of
Chen, WH, Wu, QL, Cui, GH, Liu, HL, Chen, Y, He, J   +5 more
core  

Drug combination treatment as a strategy for inhibiting human adenovirus replication. [PDF]

Antiviral Res
Dodge MJ, MacNeil KM, Tessier TM, Evans AM, Palmateer KR, Weinberg JB, Mymryk JS.   +6 more
europepmc   +1 more source