Results 81 to 90 of about 1,094 (190)

Heat shock protein 90: biological functions, diseases, and therapeutic targets

MedComm, Volume 5, Issue 2, February 2024.
Targeting the dynamic cycling of HSP90 and its interaction with co‐chaperones can promote protein maturation and client protein degradation, potentially offering effective antineoplastic strategies. Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and ...
Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Aniruddha Chatterjee, Pengxing He, Guiqin Hou   +7 more
wiley   +1 more source

A New Prenylated Flavanone from Derris trifoliata Lour.

Molecules, 2012
A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro ...
Hao Yin, Si Zhang, Zhihui Xiao, Ximin Qiu, Cheng Jiang, Xiongming Luo, Weihong He, Shengzi Liu   +7 more
doaj   +1 more source

Antiproliferative Activities and SwissADME Predictions of Physicochemical Properties of Carbonyl Group‐Modified Rotenone Analogues

ChemistryOpen, Volume 13, Issue 1, January 2024.
Rotenone derivatives were synthesized through modifications of the carbonyl group and their antiproliferative activities were evaluated against various cancer cell lines (MCF‐7, A549, and HCT116). The physicochemical properties and drug‐likeness of the derivatives were evaluated using the SwissADME webtool.
Rajelle D. Hernandez, Frances Abygail F. Genio, Jannelle R. Casanova, Marlon T. Conato, Monissa C. Paderes   +4 more
wiley   +1 more source

Using LC and Hierarchical Cluster Analysis as Tools to Distinguish Timbó Collections into Two Deguelia Species: A Contribution to Chemotaxonomy

Molecules, 2016
The species Deguelia utilis and Deguelia rufescens var. urucu, popularly known as “timbó,” have been used for many years as rotenone sources in insecticide formulations.
Danielle da Costa, Consuelo e Silva, Aline Pinheiro, Débora Frommenwiler, Mara Arruda, Giselle Guilhon, Cláudio Alves, Alberto Arruda, Milton Da Silva   +8 more
doaj   +1 more source

Deguelin induces cellular ceramide synthesis.

, 2013
Hep-2 cells were exposed to 100 µM of deguelin with or without fumonisin B1 (20 µM) for indicated time points, intracellular ceramide level was analyzed using methods mentioned above (A). Hep-2 cells were treated with fumonisin B1 (20 µM) or C6-ceramide (
Chun-cheng Lu (276392), Chao Ji (276390), Zhi-gang Bi (276391), Bing Gu (276393), Lei Cheng (171055), Rong Wang (59795), Yan-li Yang (276389)   +6 more
core   +1 more source

Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt

Cellular Physiology and Biochemistry, 2017
Background/Aims: Resveratrol is a polyphenol enriched in the skins of grapes and berries, that shows various beneficial effects for human health. In the present study, we investigated the mechanism behind the epidermal growth factor (EGF)-induced ...
Tetsu Kawabata, Haruhiko Tokuda, Kazuhiko Fujita, Shingo Kainuma, Go Sakai, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka   +7 more
doaj   +1 more source

Deguelin induces apoptosis in NZB CLL-like cells.

, 2016
(A) Mononuclear cells isolated from 8 NZB spleens were cultured in the presence of deguelin (Deg; 0–10 μM) and apoptosis was quantified at 24h. (B) Cell lysates obtained from splenic NZB cells treated with 10 μM deguelin for 24h were analyzed by western ...
Silvia Rosado (39145), Marta Morado (2622661), Juan A. Vargas-Nuñez (2622664), Nerea Rebolleda (2622655), Ignacio Losada-Fernandez (39140), Raquel Castejon (2622658), Gema Perez-Chacon (39141), Paloma Perez-Aciego (39150), Andrea Martinez (2622652), Maria Teresa Vallejo-Cremades (2622649)   +9 more
core   +1 more source

Concise Total Synthesis of (±)-Deguelin and (±)-Tephrosin Using a Vinyl Iodide as a Key Building Block

, 2018
A concise and protecting-group-free total synthesis of the antiproliferative natural product (±)-deguelin (2) was accomplished in four steps and 62% overall yield from commercially available precursors.
Shengtao Xu (513564), Guangyu Wang (553563), Aijun Lin (1393531), Jinyi Xu (1748593), Wenlong Li (571749), Hequan Yao (1393537), Feijie Xu (4852714)   +6 more
core   +1 more source

Deguelin and Paclitaxel Loaded PEG-PCL Nano-Micelles for Suppressing the Proliferation and Inducing Apoptosis of Breast Cancer Cells

Frontiers in Bioscience-Landmark
Background: Deguelin (DGL) is a natural flavonoid reported to exhibit antitumor effects in breast cancer (BC). PEG-PCL (Polyethylene Glycol- Polycaprolactone), as polymeric micelles, has biodegradability and biocompatibility. The aim of this study was to
Yali Wang, Yang Lan, Liang Wu, Shijin Zhang, Qiang Su, Qin Yang   +5 more
doaj   +1 more source

Effect of Deguelin on the growth and expression of signaling molecules in TNBC cells.

, 2013
A. Effect of deguelin on MDA-MB 231 cells in the presence of EGF (1 ng or 20 ng) alone, Deguelin alone (31–500 nM)or Deguelin+EGF. The cells were plated in six well plates, allowed to attach overnight, then treated with indicated test compound/(s) (in ...
Harshadadevi Katta (419863), Rutulkumar Patel (419864), Xinjian Peng (357087), Miguel Muzzio (419865), Genoveva Murillo (357089), Rajeshwari Mehta (419862), Fatouma Alimirah (357086), Rajendra G. Mehta (357090)   +7 more
core   +1 more source