Results 141 to 150 of about 1,019 (188)
Natural products modulating MAPK for CRC treatment: a promising strategy. [PDF]
Front PharmacolZhou L, Zhang J, Zhao K, Chen B, Sun Z.
europepmc +1 more source
Autophagy in doxorubicin resistance: basic concepts, therapeutic perspectives and clinical translation. [PDF]
Front ImmunolZhang Y, Ji Y, Tu Y, Li Y.
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Synthesis of deguelin–biotin conjugates and investigation into deguelin’s interactions
Bioorganic and Medicinal Chemistry, 2012 Deguelin, a rotenoid, has emerged as an attractive pharmacophore for chemoprevention showing in vivo activity in several xenografts. Recently, several lines of evidence have suggested its mode of action may involve inhibition of HSP90, however binding in a different mode than known pharmacophores.
Sofia Barluenga +2 more
exaly +4 more sources
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies
Pharmacological Research, 2021 Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural rotenoid, is among the class of bioactive phytoconstituents from a diverse range of plants with potential antineoplastic effects in ...
Hardeep Singh Tuli +2 more
exaly +4 more sources
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Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats
Cancer Chemotherapy and Pharmacology, 2001To study the pharmacokinetics of deguelin, a naturally occurring potential cancer chemopreventive agent, in rats.[3H]Deguelin was administered intravenously (i.v.) under anesthesia, and blood samples were collected over 24 h. [3H]Deguelin and metabolites were extracted from plasma with ethyl acetate, and quantified by HPLC.
George Udeani +2 more
exaly +3 more sources
Enhancement Radiosensitization of Breast Cancer Cells by Deguelin
Cancer Biotherapy and Radiopharmaceuticals, 2008Radiation can activate the phosphatidylinositol 3-kinase/Akt pathway and cannot downregulate survivin expression in breast cancer cells. Deguelin induces apoptosis in breast cancer cells by inhibiting pAkt and survivin expression. In this study, we assessed the effect of deguelin on radiosensitization of human breast cancer cells and its possible ...
Tongbo, Yi +3 more
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Rotenone, Deguelin, Their Metabolites, and the Rat Model of Parkinson's Disease
Chemical Research in Toxicology, 2004Rotenone and deguelin are the major active ingredients and principal components of cuberesin from Lonchocarpus utilis used as a botanical insecticide and piscicide. They are also potent complex I (NADH:ubiquinone oxidoreductase) inhibitors. Rotenone was known earlier, and deguelin is shown here to induce a Parkinson's disease (PD)-like syndrome after ...
Pierluigi, Caboni +6 more
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Effect of Deguelin on UVB-Induced Skin Carcinogenesis
Journal of Chemotherapy, 2005Nonmelanoma skin cancer afflicts more than one million people in the U.S. annually, highlighting the need for more effective preventive regimens. We have investigated the ability of deguelin, a plant-derived rotenoid with cancer chemopreventive activity, to inhibit UVB-induced skin carcinogenesis with the SKh-1 mouse model.
J J, Gills +4 more
openaire +2 more sources