Results 141 to 150 of about 1,094 (192)

Protective effects of harpagoside on mitochondrial functions in rotenone‑induced cell models of Parkinson's disease. [PDF]

Biomed Rep
Lang J, Xiong Z.
europepmc   +1 more source

Accurate prediction of drug-target interactions in Chinese and western medicine by the CWI-DTI model. [PDF]

Sci Rep
Li Y, Zhang X, Chen Z, Yang H, Liu Y, Wang H, Yan T, Xiang J, Wang B.   +8 more
europepmc   +1 more source

PathoAnalyzer-I: An Integrative Bioinformatics Platform for Chronic Disease Analysis. [PDF]

Bioinform Biol Insights
Aguerd A, Bennis F, Chegdani F.
europepmc   +1 more source

Antioxidant curcumin induces oxidative stress to kill tumor cells (Review). [PDF]

Oncol Lett
Hu Y, Cheng L, Du S, Wang K, Liu S.
europepmc   +1 more source

Synthesis of deguelin–biotin conjugates and investigation into deguelin’s interactions

Bioorganic and Medicinal Chemistry, 2012
Deguelin, a rotenoid, has emerged as an attractive pharmacophore for chemoprevention showing in vivo activity in several xenografts. Recently, several lines of evidence have suggested its mode of action may involve inhibition of HSP90, however binding in a different mode than known pharmacophores.
Nicolas Winssinger, Sofia Barluenga, Katarzyna Górska   +2 more
exaly   +4 more sources

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Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats

Cancer Chemotherapy and Pharmacology, 2001
To study the pharmacokinetics of deguelin, a naturally occurring potential cancer chemopreventive agent, in rats.[3H]Deguelin was administered intravenously (i.v.) under anesthesia, and blood samples were collected over 24 h. [3H]Deguelin and metabolites were extracted from plasma with ethyl acetate, and quantified by HPLC.
George Udeani, John M Pezzuto, Jérôme W Kosmeder   +2 more
exaly   +3 more sources

Enhancement Radiosensitization of Breast Cancer Cells by Deguelin

Cancer Biotherapy and Radiopharmaceuticals, 2008
Radiation can activate the phosphatidylinositol 3-kinase/Akt pathway and cannot downregulate survivin expression in breast cancer cells. Deguelin induces apoptosis in breast cancer cells by inhibiting pAkt and survivin expression. In this study, we assessed the effect of deguelin on radiosensitization of human breast cancer cells and its possible ...
Tongbo, Yi, Haizhi, Li, Xuanyi, Wang, Zhengyan, Wu   +3 more
openaire   +2 more sources

Effect of Deguelin on UVB-Induced Skin Carcinogenesis

Journal of Chemotherapy, 2005
Nonmelanoma skin cancer afflicts more than one million people in the U.S. annually, highlighting the need for more effective preventive regimens. We have investigated the ability of deguelin, a plant-derived rotenoid with cancer chemopreventive activity, to inhibit UVB-induced skin carcinogenesis with the SKh-1 mouse model.
J J, Gills, J, Kosmeder, R C, Moon, D D, Lantvit, J M, Pezzuto   +4 more
openaire   +2 more sources

Rotenone, Deguelin, Their Metabolites, and the Rat Model of Parkinson's Disease

Chemical Research in Toxicology, 2004
Rotenone and deguelin are the major active ingredients and principal components of cuberesin from Lonchocarpus utilis used as a botanical insecticide and piscicide. They are also potent complex I (NADH:ubiquinone oxidoreductase) inhibitors. Rotenone was known earlier, and deguelin is shown here to induce a Parkinson's disease (PD)-like syndrome after ...
Pierluigi, Caboni, Todd B, Sherer, Nanjing, Zhang, Georgia, Taylor, Hye Me, Na, J Timothy, Greenamyre, John E, Casida   +6 more
openaire   +4 more sources

Deguelin and Its Role in Chronic Diseases

2016
Deguelin is one of four major naturally occurring rotenoids isolated from root extracts and is best recognized as a NADH: ubiquinone oxidoreductase (complex I) inhibitor, resulting in significant alterations in mitochondrial function. Deguelin has also been implicated as a regulator of apoptosis through signaling pathways, such as the (PI3K)/Akt ...
Jonathan, Boyd, Alice, Han
openaire   +2 more sources