Results 151 to 160 of about 1,629 (181)
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Synthesis of deguelin–biotin conjugates and investigation into deguelin’s interactions
Bioorganic & Medicinal Chemistry, 2012Deguelin, a rotenoid, has emerged as an attractive pharmacophore for chemoprevention showing in vivo activity in several xenografts. Recently, several lines of evidence have suggested its mode of action may involve inhibition of HSP90, however binding in a different mode than known pharmacophores.
Garcia, José +4 more
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Antiangiogenic Effect of Deguelin on Choroidal Neovascularization
The Journal of Pharmacology and Experimental Therapeutics, 2008Age-related macular degeneration is the leading cause of blindness in the elderly. Choroidal neovascularization (CNV) leads to severe vision loss in patients of age-related macular degeneration. Previously, we have demonstrated that deguelin, isolated from plants in the Mundulea sericea family, is a chemopreventive agent.
Jeong Hun, Kim +6 more
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Enhancement Radiosensitization of Breast Cancer Cells by Deguelin
Cancer Biotherapy and Radiopharmaceuticals, 2008Radiation can activate the phosphatidylinositol 3-kinase/Akt pathway and cannot downregulate survivin expression in breast cancer cells. Deguelin induces apoptosis in breast cancer cells by inhibiting pAkt and survivin expression. In this study, we assessed the effect of deguelin on radiosensitization of human breast cancer cells and its possible ...
Tongbo, Yi +3 more
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Deguelin and Its Role in Chronic Diseases
2016Deguelin is one of four major naturally occurring rotenoids isolated from root extracts and is best recognized as a NADH: ubiquinone oxidoreductase (complex I) inhibitor, resulting in significant alterations in mitochondrial function. Deguelin has also been implicated as a regulator of apoptosis through signaling pathways, such as the (PI3K)/Akt ...
Jonathan, Boyd, Alice, Han
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Effect of Deguelin on UVB-Induced Skin Carcinogenesis
Journal of Chemotherapy, 2005Nonmelanoma skin cancer afflicts more than one million people in the U.S. annually, highlighting the need for more effective preventive regimens. We have investigated the ability of deguelin, a plant-derived rotenoid with cancer chemopreventive activity, to inhibit UVB-induced skin carcinogenesis with the SKh-1 mouse model.
J J, Gills +4 more
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Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats
Cancer Chemotherapy and Pharmacology, 2001To study the pharmacokinetics of deguelin, a naturally occurring potential cancer chemopreventive agent, in rats.[3H]Deguelin was administered intravenously (i.v.) under anesthesia, and blood samples were collected over 24 h. [3H]Deguelin and metabolites were extracted from plasma with ethyl acetate, and quantified by HPLC.
G O, Udeani +8 more
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Agricultural and Biological Chemistry, 1961
Starting with resorcinol, the total synthesis of dl-deguelin (VI) was accomplished. In the course of this investigation, dihydrodeguelic acid (II), dihydroisodeguelic acid (X), dihydro-dehydrodeguelin (III), dehydrodeguelin (IV), dl-deguelol (V) and dihydro-β-rotenonone (XI) were prepared.
Hiroshi Fukami +3 more
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Starting with resorcinol, the total synthesis of dl-deguelin (VI) was accomplished. In the course of this investigation, dihydrodeguelic acid (II), dihydroisodeguelic acid (X), dihydro-dehydrodeguelin (III), dehydrodeguelin (IV), dl-deguelol (V) and dihydro-β-rotenonone (XI) were prepared.
Hiroshi Fukami +3 more
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Rotenone, Deguelin, Their Metabolites, and the Rat Model of Parkinson's Disease
Chemical Research in Toxicology, 2004Rotenone and deguelin are the major active ingredients and principal components of cuberesin from Lonchocarpus utilis used as a botanical insecticide and piscicide. They are also potent complex I (NADH:ubiquinone oxidoreductase) inhibitors. Rotenone was known earlier, and deguelin is shown here to induce a Parkinson's disease (PD)-like syndrome after ...
Pierluigi, Caboni +6 more
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Involvement of SRC-3 in deguelin-induced apoptosis in Jurkat cells
International Journal of Hematology, 2009The aim of the study was to investigate the anticancer effects and the molecular mechanisms of deguelin on Jurkat cells. Cell viability was assessed by MTT assay. Terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assay and transmission electron microscopy were used to detect cell apoptosis.
Shu, W-X +4 more
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Total synthesis of (−)-deguelin via an iterative pyran-ring formation strategy
Chemical Communications, 2015Asymmetric synthesis of (−)-deguelin has been accomplished via iterative pyran-ring formation of the O- and C-arylation precursor prepared by an anionic addition of a chromene unit to aryloxy alkyl aldehyde.
Seungbeom, Lee +7 more
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