Results 141 to 150 of about 1,195 (187)
Molecules, 2014 Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung metastasis is the main cause of death in those patients. Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to exhibit cytotoxic
Hung-Sheng Shang +2 more
exaly +4 more sources
Deguelin Targets Multiple Oncogenic Signaling Pathways to Combat Human Malignancies
Pharmacological Research, 2021 Cancer is an anomalous growth and differentiation of cells known to be governed by oncogenic factors. Plant-based natural metabolites have been well recognized to possess chemopreventive properties. Deguelin, a natural rotenoid, is among the class of bioactive phytoconstituents from a diverse range of plants with potential antineoplastic effects in ...
Manoj Kumar +2 more
exaly +4 more sources
Efficacy of Deguelin and Silibinin on Benzo(a)Pyrene-Induced Lung Tumorigenesis in A/J Mice
Neoplasia, 2005 We evaluated deguelin and silibinin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene (BP) for their ability to inhibit pulmonary adenoma formation and growth. Animals were treated with either deguelin (5.0 or 10.0 mg/kg body weight,
Ming You, Ronald A Lubet, Yian Wang
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Pharmacokinetics of Deguelin, a Cancer Chemopreventive Agent in Rats
Cancer Chemotherapy and Pharmacology, 2001To study the pharmacokinetics of deguelin, a naturally occurring potential cancer chemopreventive agent, in rats.[3H]Deguelin was administered intravenously (i.v.) under anesthesia, and blood samples were collected over 24 h. [3H]Deguelin and metabolites were extracted from plasma with ethyl acetate, and quantified by HPLC.
George Udeani +2 more
exaly +3 more sources
Deguelin, a Novel Anti-Tumorigenic Agent in Human Esophageal Squamous Cell Carcinoma
EBioMedicine, 2017 Yuh Baba, Yasumasa Kato
exaly +3 more sources
Enhancement Radiosensitization of Breast Cancer Cells by Deguelin
Cancer Biotherapy and Radiopharmaceuticals, 2008Radiation can activate the phosphatidylinositol 3-kinase/Akt pathway and cannot downregulate survivin expression in breast cancer cells. Deguelin induces apoptosis in breast cancer cells by inhibiting pAkt and survivin expression. In this study, we assessed the effect of deguelin on radiosensitization of human breast cancer cells and its possible ...
Tongbo, Yi +3 more
openaire +2 more sources
Rotenone, Deguelin, Their Metabolites, and the Rat Model of Parkinson's Disease
Chemical Research in Toxicology, 2004Rotenone and deguelin are the major active ingredients and principal components of cuberesin from Lonchocarpus utilis used as a botanical insecticide and piscicide. They are also potent complex I (NADH:ubiquinone oxidoreductase) inhibitors. Rotenone was known earlier, and deguelin is shown here to induce a Parkinson's disease (PD)-like syndrome after ...
Pierluigi, Caboni +6 more
openaire +4 more sources
Effect of Deguelin on UVB-Induced Skin Carcinogenesis
Journal of Chemotherapy, 2005Nonmelanoma skin cancer afflicts more than one million people in the U.S. annually, highlighting the need for more effective preventive regimens. We have investigated the ability of deguelin, a plant-derived rotenoid with cancer chemopreventive activity, to inhibit UVB-induced skin carcinogenesis with the SKh-1 mouse model.
J J, Gills +4 more
openaire +2 more sources
Deguelin and Its Role in Chronic Diseases
2016Deguelin is one of four major naturally occurring rotenoids isolated from root extracts and is best recognized as a NADH: ubiquinone oxidoreductase (complex I) inhibitor, resulting in significant alterations in mitochondrial function. Deguelin has also been implicated as a regulator of apoptosis through signaling pathways, such as the (PI3K)/Akt ...
Jonathan, Boyd, Alice, Han
openaire +2 more sources
Agricultural and Biological Chemistry, 1961
Starting with resorcinol, the total synthesis of dl-deguelin (VI) was accomplished. In the course of this investigation, dihydrodeguelic acid (II), dihydroisodeguelic acid (X), dihydro-dehydrodeguelin (III), dehydrodeguelin (IV), dl-deguelol (V) and dihydro-β-rotenonone (XI) were prepared.
Hiroshi Fukami +3 more
openaire +1 more source
Starting with resorcinol, the total synthesis of dl-deguelin (VI) was accomplished. In the course of this investigation, dihydrodeguelic acid (II), dihydroisodeguelic acid (X), dihydro-dehydrodeguelin (III), dehydrodeguelin (IV), dl-deguelol (V) and dihydro-β-rotenonone (XI) were prepared.
Hiroshi Fukami +3 more
openaire +1 more source