Results 51 to 60 of about 602,095 (309)

Imaging of RNA in situ hybridization by atomic force microscopy [PDF]

, 1996
In this study we investigated the possibility of imaging internal cellular molecules after cytochemical detection with atomic force microscopy (AFM). To this end, rat 9G and HeLa cells were hybridized with haptenized probes for 28S ribosomal RNA, human ...
Corput, M.P.C. van de, Grooth, B.G. de, Kalle, W.H.J., Macville, M.V.E., Raap, A.K., Tanke, H.J.   +5 more
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Prevalence and Risk Factors of Diarrhoea among Critically Ill Patients in Intensive Care Units: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Diarrhoea is common in critically ill patients that may be caused due to many factors such as Clostridium difficile, drugs (e.g., laxatives, antibiotics) and enteral feeds. The incidence of diarrhoea in the Intensive Care Units (ICU)
Karishma Khaund, Pinaki Bayan, Ningcingyile Ramlia, Khamti Mary Lyngdoh Lyngkhoi, Sangita Paul, Mridusmita Pathak, Siddhartha Goswami, Deepom Sharma   +7 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Exercise-induced whole-body dehydration does not affect airway responsiveness in athletes but may impair small airway function [PDF]

, 2015
Exercise-induced bronchoconstriction (EIB) is the transient narrowing of the airways that occurs during or shortly after strenuous exercise. Loss of water from the airway surface, due to the conditioning of large volumes of air during exercise, is the ...
Kippelen, P, Romer, L, Simpson, A
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Determination of weight loss methods and effects among wrestlers before an official championship

Frontiers in Nutrition
IntroductionIt is known that combat athletes frequently lose weight before a competition. This study aimed to determine the weight loss methods before an official championship and the effects of these weight loss methods on the performance of wrestlers ...
Ramazan Seker, Ozkan Isik, Erdil Durukan, Meric Eraslan, Laurentiu-Gabriel Talaghir, Viorel Dorgan   +5 more
doaj   +1 more source

Numerical method for solving multipoints elliptic-parabolic equation for dehydration process [PDF]

, 2012
Drying is the oldest and efficient form of preserving fruits. This research focuses on the mathematical modeling of tropical fruits dehydration using instant controlled pressure drop (Détente Instantanée Controlée or known as DIC) technique.
Alias, Norma, Che Abd. Ghani, Asnida, Saipan@Saipol, Hafizah Farhah   +2 more
core