Results 81 to 90 of about 3,505 (190)
Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley +1 more source
BIOTRANSFORMATION OF DEHYDROABIETIC ACID BY ACTINOBACTERIA [PDF]
, 2014 Resin acids are the group of diterpene carboxylic acids which constitute a large part of ecotoxic agents in kraft pulp mill effluents. Penetration of these recalcitrant, biologically active and toxic ecopollutants (even at low concentrations) into the ...
Cheremnikh, K. M. +1 more
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Organocatalytic C─O Bond Cleavage and Asymmetric Transformations via [1,3]‐Sigmatropic Rearrangement
Advanced Science, Volume 12, Issue 29, August 7, 2025.A direct asymmetric strategy for fulfilling the functional group transfer by aryl ether cleavage and migration is developed, representing the first Brønsted base‐catalyzed asymmetric [1,3]‐sigmatropic rearrangement reaction. The resulting chiral benzofuran products generated through this strategy exhibit significant 3D‐dimensionality and demonstrate ...
Lei Peng +7 more
wiley +1 more source
Composition of Myroxylon pereirae Resin and Colophonium for Patch Testing
Contact Dermatitis, Volume 93, Issue 2, Page 108-113, August 2025.The compositions of two samples of Myroxylon pereirae resin (balsam of Peru) and of colophonium used for patch testing were analysed with gas chromatography–mass spectrometry/flame ionisation detection (GC–MS/FID) of the volatile components obtained by headspace SPME (solid phase microextraction). The main constituents in M.
Anton de Groot +4 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 28, Issue 28, July 29, 2025.In this work, 1,1′‐carbonyldiimidazole, a relatively inexpensive reagent with inherently low toxicity, is utilized to activate polar natural products containing carboxylic acids and alcohols to enable the formation of less polar species (N‐acylimidazoles and N‐acyloxymidazoles).
Moses M. Mutungi +3 more
wiley +1 more source
Fluorescent properties and in vitro studies of new dehydroabietic acid-based diarylamines fluorescent probes [PDF]
Frontiers of Agricultural Science and Engineering, 2017 A series of dehydroabietic acid-based diarylamines have been synthesized in order to investigate their fluorescent properties, photostability, cell toxicity and in vitro fluorescence imaging.
Hong GAO,Jie SONG,Shibin SHANG,Zhanqian SONG
doaj +1 more source
Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells [PDF]
, 2012 The aim of this study was to use whole cell catalysts as tools for modification of selected resin acids in order to obtain value-added functional derivatives.
Oksman-Caldentey, Kirsi-Marja; id_orcid +11 more
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Angewandte Chemie International Edition, Volume 64, Issue 25, June 17, 2025.We present a metal‐free method for aromatic deuterium labeling via photoexcitation in deuterated HFIP. This approach leverages the enhanced basicity of excited‐state aromatics to achieve selective hydrogen isotope exchange at challenging positions. Demonstrated on complex drug molecules, this efficient strategy provides a valuable tool for isotope ...
Eva Rivera‐Chao +5 more
wiley +1 more source
Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.Phacidium infestans DSM 5139 was studied for its ability to penetrate pine needles and overcome their inhibitory compounds. Using mass spectrometry and genome mining, we identified the biological and molecular strategies enabling nutrient acquisition and resilience against chemical stress, providing insights into the survival mechanisms of this cold ...
Chahira Zerouki +5 more
wiley +1 more source
Benzylic C–H oxidations of dehydroabietic acid derivatives at positions 7 and 15 [PDF]
, 2016 Dehydroabietic acid is a natural diterpene readily available from disproportionated rosin. This natural product has attracted the interest of both the synthetic, medical and pharmacological communities due to the wide variety of important biological ...
Krogerus, Sara
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