Results 1 to 10 of about 276 (148)

Occurrence of isomeric dehydrocholesterols in human plasma.

Journal of Lipid Research, 1991
Three isomeric dehydrocholesterols were found in plasma from healthy subjects and patients with abnormal production or metabolism of cholesterol.
M Axelson
doaj   +4 more sources

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism. [PDF]

Proc Natl Acad Sci U S A, 2020
Dysregulated cholesterol metabolism is implicated in a number of neurological disorders. Many sterols, including cholesterol and its precursors and metabolites, are biologically active and important for proper brain function. However, spatial cholesterol
Yutuc E, Angelini R, Baumert M, Mast N, Pikuleva I, Newton J, Clench MR, Skibinski DOF, Howell OW, Wang Y, Griffiths WJ.   +10 more
europepmc   +4 more sources

Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates. [PDF]

J Steroid Biochem Mol Biol, 2021
Bile acids are the end products of cholesterol metabolism secreted into bile. They are essential for the absorption of lipids and lipid soluble compounds from the intestine.
Abdel-Khalik J, Hearn T, Dickson AL, Crick PJ, Yutuc E, Austin-Muttitt K, Bigger BW, Morris AA, Shackleton CH, Clayton PT, Iida T, Sircar R, Rohatgi R, Marschall HU, Sjövall J, Björkhem I, Mullins JGL, Griffiths WJ, Wang Y.   +18 more
europepmc   +4 more sources

Neutral sterols of rat epididymis: high concentrations of dehydrocholesterols in rat caput epididymidis

Journal of Lipid Research, 2001
Phospholipids and sterols are known to have multiple functions in reproductive tissue of mammals. High concentrations of the cholesterol precursor desmosterol have been described in testis, epididymis, and spermatozoa of various species.
Bernhard Lindenthal, Tayseer A. Aldaghlas, Joanne K. Kelleher, Stephan M. Henkel, René Tolba, Gerhard Haidl, Klaus von Bergmann   +6 more
doaj   +3 more sources

Synthese van nieuwe sterolen en provitamines D met gewijzigde zijketen [PDF]

, 1951
All sterols which obtain antirachitic activity by ultraviolet irradiation show a conjugated system of double bonds (5,7) in ring B and a hydroxyl group at C3 in the cyclopentanoperhydrophenanthrene skeleton. ...
de Vries, Harmen
core   +10 more sources

Sterol profiles in plasma and erythrocyte membranes in patients with Smith-Lemli-Opitz syndrome: a six-year experience [PDF]

, 2011
Background: This study reports our experience over the last six years in the diagnosis of Smith-Lemli-Opitz syndrome and other inborn errors of cholesterol biosynthesis.
A. Nappi, DELLO RUSSO, ANTONIO, G. Corso, GELZO, MONICA, P. Pianese, R. Barone, S. Clericuzio   +6 more
core   +2 more sources

Stability study of dehydrocholesterols in dried spot of blood from patients with Smith–Lemli–Opitz syndrome, using filter-paper treated with butylated hydroxytoluene [PDF]

, 2012
Considering the clinical importance of implementing a screening method for cholesterol and dehydrocholesterols in dried blood spot, this study aims to standardize the preanalytical variability of DHC in DBS for detecting SLOS by using filter paper ...
DELLO RUSSO, ANTONIO, G. Corso, GELZO, MONICA   +2 more
core   +2 more sources

Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7α-hydroxylase and 27-hydroxylase activities in rat liver

Journal of Lipid Research, 1999
The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3β-hydroxysterol Δ7-reductase, the final enzyme in the cholesterol biosynthetic pathway.
Akira Honda, Gerald Salen, Sarah Shefer, Ashok K. Batta, Megumi Honda, Guorong Xu, G. Stephen Tint, Yasushi Matsuzaki, Junichi Shoda, Naomi Tanaka   +9 more
doaj   +1 more source

Markedly increased tissue concentrations of 7-dehydrocholesterol combined with low levels of cholesterol are characteristic of the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 1995
The Smith-Lemli-Opitz syndrome is an autosomal recessive birth defect (frequency 1:20,000-1:40,000) that results in profound mental retardation, physical deformities, and failure to thrive.
G S Tint, M Seller, R Hughes-Benzie, A K Batta, S Shefer, D Genest, M Irons, E Elias, G Salen   +8 more
doaj   +1 more source

Non-invasive determination of the sun protection factor on the human skin with a spectroscopic device in the whole UV range [PDF]

, 2023
Die Bestimmung des Lichtschutzfaktors (LSF) von Sonnenschutzmitteln erfolgt aktuell durch ein invasives Verfahren, bei dem Proband*innen genau den UV-Strahlen ausgesetzt werden, vor denen die Testprodukte sie eigentlich schützen sollten. Eine alternative
Throm, Carolin
core   +1 more source