Can I have some sunshine to cheer me up? Vitamin D deficiency and depression in the elderly [PDF]
, 2011 Vitamine D-deficiëntie komt bij ouderen frequent voor; bij ouderen met een psychiatrische stoornis is het risico waarschijnlijk nog groter. Vitamine D speelt een belangrijke rol bij de calciumhomeostase, maar onlangs zijn ook studies verschenen die ...
Gaasbeek, A. B. +3 more
core +4 more sources
Down syndrome serum screening also identifies an increased risk for multicystic dysplastic kidney, two-vessel cord, and hydrocele [PDF]
, 2008 The FASTER trial compared 1st and 2nd trimester screening methods for aneuploidy. We examined relationships between maternal serum markers and common congenital anomalies in the pediatric outcome data set of 36,837 ...
Berkowitz, Richard L. +17 more
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Unusual detection of lathosterol in amniotic fluids investigated for the determination of cholesterol and 7-dehydrocholesterol for suspected Smith-Lemli-Opitz Syndrome [PDF]
, 2014 The Smith-Lemli-Opitz syndrome (SLOS), is an autosomal recessive disorder caused by a 7-dehydrocholesterol reductase deficiency, which is characterized by abnormally elevated amniotic fluid 7-DHC (7-dehydrocholesterol) concentrations.
A. Barlocco +7 more
core +1 more source
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis [PDF]
, 2021 Abstract Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation exploited by tumours to counteract phospholipid oxidation.
Jose Pedro Friedmann Angeli +30 more
openaire +1 more source
Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction [PDF]
Biotechnology for Biofuels, 2018 7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3. Microbial production of 7-DHC from simple carbon has been recognized as an attractive complement to the traditional sources.
Xiao-Jing Guo +7 more
openaire +3 more sources
Human Cholesterol Biosynthesis Defects [PDF]
, 2019 Cholesterol plays an essential role in normal embryogenesis and perturbations in its de novo synthesis are responsible for organ malformations in the cholesterol biosynthesis defects.
Anderson, Erin, Coman, David
core +1 more source
Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation
Advanced Science, EarlyView.The relative abundance of peroxidation‐resistant monounsaturated fatty acids (MUFAs) vs. peroxidation‐sensitive polyunsaturated fatty acids (PUFAs) incorporated into phospholipid (PL) is a key determinant of ferroptosis sensitivity, as the peroxidation of PL PUFA acyl chains (PUFA‐PL) disrupts membrane integrity, causing ferroptotic cell death ...
Shaojie Cui, Jin Ye
wiley +1 more source
Fetal and neonatal environment:effects on bile acid and lipid metabolism [PDF]
, 2012 Ondervoeding van de foetus kan het risico op chronische aandoeningen als diabetes, obesitas, hart- en vaatziekten en een verstoorde vetstofwisseling verhogen.
Meer, Hester van
core +6 more sources
Etablierung und Optimierung umweltfreundlicher Prozesse zur Modifikation steroidaler Verbindungen mittels Ganzzellkatalysen [PDF]
, 2020 Steroidale Verbindungen regulieren u.a. die Mineralstoff-Homöostaste, sowie Immun- und Entzündungsreaktionen und sind daher von hoher pharmazeutischer Relevanz.
König, Lisa
core +1 more source
7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2011 7-Dehydrocholesterol reductase (DHCR7) catalyzes the final step in cholesterol synthesis. The enzyme utilizes NADPH as a source of electrons and has been reported to require NADPH-cytochrome P450 reductase (POR) as its redox partner. To test this hypothesis, microsomes were prepared from the livers of mice in which hepatic cytochrome P450 reductase ...
Ling, Zou, Li, Li, Todd D, Porter
openaire +2 more sources