Lead optimisation of dehydroemetine for repositioned use in malaria
Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubakker, Muna +8 more
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Pharmacodynamic effects of dehydroemetine
, 1972 The pharmacodynamics of dehydroemetine were studied in isolated preparations and in whole animals. Dehydroemetine had no effect on the guinea-pig isolated ileum but non-specifically antagonized the spasmogenic effect of histamine, acetylcholine and ...
L A SALAKO
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Lead optimisation of dehydroemetine as an antimalarial option through drug repositioning and molecular modelling [PDF]
Malaria is a life-threatening infectious disease caused by a parasitic protozoan belonging to the genus Plasmodium. Resistance has started to emerge for the currently recommended artemisinin combination therapies used to treat malaria.
Panwar, P
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The expectorant action of cephaeline, emetine and 2-dehydroemetine
, 1964 Cephaeline, emetine and 2-dehydroemetine were administered, as the dihydrochlorides, in doses from 0.1 to 81 mg/kg body weight, orally and subcutaneously to 135 rabbits and 92 cats arranged for the collection of respiratory tract fluid.
Lois M Knight, Eldon M Boyd
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Metronidazoleとtinidazoleが効果を示さず多量のシストを排出し免疫反応が陰性であったアメーバ赤痢の二症例 [PDF]
, 1984 Two cases of amoebic dysentery with ineffectiveness of metronidazole and tinidazole were reported. Patients were admitted to the hospital because of diarrhea and protein loosing enteropathy. The patient of the first case was a 73-year-old man who has had
末長, 正弘 +11 more
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Therapy of Alveococcosis in Man
, 2016 Diagnostic, therapeutic and prognostic aspects are interpreted on the basis of two cases of Echinococcus alveolaris. Both patients had undergone partial hepatectomy and were subsequently treated chemotherapeutically.
Gyr, K, Lüdin, C E, Karoussos, K
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Two Case Reports of Entamoeba histolytica with Ineffectiveness of Metronidazole and Tinidazole, Excreting a Huge Number of Cysts and Showing Negative Immunological Reactions [PDF]
, 1984 Two cases of amoebic dysentery with ineffectiveness of metronidazole and tinidazole were reported. Patients were admitted to the hospital because of diarrhea and protein loosing enteropathy. The patient of the first case was a 73-year-old man who has had
末長, 正弘 +11 more
core
Oral dehydroemetine (DHE) in intestinal and extra intestinal amebiasis. A preliminary report
, 1967 This article does not have an ...
Mehta, A. B., Patel, J. C.
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Divergent total syntheses of ITHQ-type bis-β-carboline alkaloids by regio-selective formal aza-[4 + 2] cycloaddition and late-stage C-H functionalization. [PDF]
Chem Sci, 2023 Wang Q, Guo F, Wang J, Lei X.
europepmc +1 more source
Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from Picrasma quassioides, Inhibits Metastasis of Head and Neck Squamous Cell Carcinoma. [PDF]
Int J Mol Sci, 2023 Ho HY +5 more
europepmc +1 more source