Results 51 to 60 of about 12,662 (158)

Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Sarcopenia is an age‐related condition characterized by progressive muscle mass, strength and physical performance declines, contributing to frailty and adverse health outcomes. Despite increasing interest in molecular biomarkers, longitudinal data with external validation are limited.
Sung Hye Kong, Ok Hee Jeon, Ji Yeon Kim, Miji Kim, Jinhee Kim, Seung Shin Park, Hak Chul Chang, Chang Won Won, Dohyun Han   +8 more
wiley   +1 more source

Behavioral correlates of dehydroepiandrosterone and dehydroepiandrosterone sulfate

The Aging Male, 1998
The actions of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) on the central nervous system have been described as neurotropic, excitatory, and neuromodulator and may form the basis of various psychological effects in humans. Two research strategies help to define a possible role for DHEA and DHEAS in human behavior: first, to
openaire   +1 more source

Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming, Abdul‐Akim Guseinov, Irina G. Tikhonova, Graeme Milligan, Nicole A. Perry‐Hauser   +4 more
wiley   +1 more source

Migraine and cluster headache show impaired neurosteroids patterns

The Journal of Headache and Pain, 2019
Background Perturbation of neuronal excitability contributes to migraine. Neurosteroids modulate the activity of γ-aminobutyric acid A and N-methyl-d-aspartate receptors, and might be involved in the pathogenesis of migraine.
Angela Koverech, Claudia Cicione, Luana Lionetto, Marta Maestri, Francesco Passariello, Elisabetta Sabbatini, Matilde Capi, Cristiano Maria De Marco, Martina Guglielmetti, Andrea Negro, Luisa Di Menna, Maurizio Simmaco, Ferdinando Nicoletti, Paolo Martelletti   +13 more
doaj   +1 more source

Physiological Responses to Virtual Reality‐Based Stress Regulation and Relaxation Interventions: A Systematic Review

Stress and Health, Volume 42, Issue 2, April 2026.
ABSTRACT Physiological markers are increasingly used to monitor individuals undergoing Virtual Reality (VR) stress interventions. However, several challenges arise when employing these markers to assess the impact of VR stress interventions. This systematic review synthesises and critically discusses the literature on VR stress interventions across ...
Lisanne M. Robbemond, Matthijs L. Noordzij, Catheleine M. G. van Driel, Wim Veling   +3 more
wiley   +1 more source

Maternal serum Dehydroepiandrosterone Sulfate levels and the efficiency of labor [PDF]

Acta Medica Iranica, 2001
To evaluate the maternal serum dehydroepiandrosterone (DHEA) sulfate levels as a factor influencing labor ‘efficiency’ at term and unsuccessful labor induction. This is a prospective study.
"Modares Gilani M, Peikari N, Ziai S, Faghihzadeh B "   +3 more
doaj   +2 more sources

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

Sex Hormones Associate With Amyotrophic Lateral Sclerosis Risk and Survival

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 612-617, March 2026.
ABSTRACT Amyotrophic lateral sclerosis (ALS) risk differs by sex and age, implicating sex hormones as potential modifiers. This study examined plasma levels of biologically active sex hormones and their association with ALS odds and survival in cases (females n = 131, males n = 189) and controls (females n = 138, males n = 150) from the University of ...
Stephen A. Goutman, David G. Stouffer, Dae‐Gyu Jang, Jihyun Park, Benjamin J. Murdock, Richard J. Auchus   +5 more
wiley   +1 more source

Changes in androstenedione, dehydroepiandrosterone, testosterone, estradiol, and estrone over the menopausal transition

Women's Midlife Health, 2017
Background Previous reports have noted that dehydroepiandrosterone-sulfate (DHEAS) increases prior to the final menstrual period (FMP) and remains stable beyond the FMP.
Catherine Kim, Siobàn D. Harlow, Huiyong Zheng, Daniel S. McConnell, John F. Randolph   +4 more
doaj   +1 more source

Evaluating Potential Effects of Chamomile (Matricaria chamomilla L.) in Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Chamomile contains different bioactive agents such as flavonoids and phytosterols with potential anti‐inflammatory, antioxidant, analgesic, antispasmodic, and antitumor characteristics. According to our findings, animal studies have demonstrated the potential benefits of Chamomile consumption in the treatment of PCOS. In contrast, human studies yielded
Zahra Firoozi, Roghayeh Molani‐Gol, Vahideh Ebrahimzadeh‐Attari, Aida Malek‐Mahdavi   +3 more
wiley   +1 more source