Results 101 to 110 of about 1,224,293 (342)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Impacts of the transgenic CrylAc and CpTI insect-resistant cotton SGK321 on selected soil enzyme activities in the rhizosphere

Plant, Soil and Environment, 2014
Transgenic CrylAc and CpTI insect-resistant cotton SGK321 is widely adopted for many years in several regions of China, however the understanding of its potential effects on soil enzyme activities is not studied.
Y.J. Zhang, M. Xie, C.Y. Li, G. Wu, D.L. Peng   +4 more
doaj   +1 more source

Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation [PDF]

, 2014
Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs).
Gallagher, Connor, Marsh, Andrew, Millard, Andrew D., Scanlan, David J., Taylor, Paul C.   +4 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Simulation of a surface spill of different diesel/biodiesel mixtures in an ultisol, using natural attenuation and bioaugmentation/biostimulation

Anais da Academia Brasileira de Ciências
Accidents caused by leaks and/or spills on soils need to be addressed. Natural attenuation, biostimulation and bioaugmentation can be useful bioremediation strategies for decontamination processes in soils of diesel/biodiesel mixtures.
DANIEL D. MEYER, SABRINA A. BEKER, KARINA HECK, MARIA DO CARMO R. PERALBA, FÁTIMA M. BENTO   +4 more
doaj   +1 more source

ATIVIDADE MICROBIANA E PROPRIEDADES BIOQUÍMICAS DO SOLO RESULTANTES DA APLICAÇÃO DE GESSO AGRÍCOLA NA CULTURA DO REPOLHO

Scientia Agricola, 1997
Este estudo investigou o impacto da aplicação de gesso agrícola e de uma fonte rica em enxofre sobre as características microbianas e bioquímicas de um latossolo vermelho escuro cultivado com repolho.
E. NAHAS, J.H. DELFINO, L.C. ASSIS
doaj   +1 more source

DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma [PDF]

, 2010
Brock C. Christensen, Ashley A. Smith, Shichun Zheng, Devin C. Koestler, E. Andrés Houseman, Carmen J. Marsit, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas, Margaret Wrensch, Karl T. Kelsey, John K. Wiencke   +11 more
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Evolução de CO2 e atividades enzimáticas em amostras de solo tratado com herbicidas CO2 evolution and enzymatic activites in herbicide-treated soil samples

Planta Daninha, 2009
Os efeitos dos herbicidas bentazon, metolachlor, trifluralin, imazethapyr, imazethapyr+lactofen, haloxyfop-methyl, glyphosate e chlorimuron-ethyl, testados em duas concentrações (duas e dez vezes a dose média recomendada por hectare), sobre a atividade ...
G. Fernandez, R.A. Pitelli, M. Cadenazzi
doaj   +1 more source