Results 101 to 110 of about 1,320,603 (414)

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]

, 2014
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P., Billker, Oliver, Creek, Darren J., Limenitakis, Julien, Macrae, James I., McConville, Malcolm J., Modrzynska, Katarzyna K., Oppenheim, Rebecca D., Pino, Paco, Polonais, Valerie, Seeber, Frank, Soldati-Favre, Dominique   +11 more
core   +1 more source

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

BMC Proceedings, 2012
Most tumors display enhanced glucose metabolism compared to normal tissues [1-6]. The preferential conversion of glucose to lactate in cancer cells (the Warburg Effect) was one of the first known differences between tumor and normal cells and is believed
J. Locasale, A. Grassian, R. Beroukhim, M. Meyerson, G. Wagner, J. Asara, J. Brugge, M. V. Vander Heiden, L. Cantley   +8 more
semanticscholar   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Modulating Substrate Specificity of Rhizobium sp. Histamine Dehydrogenase through Protein Engineering for Food Quality Applications

Molecules, 2023
Histamine is a biogenic amine found in fish-derived and fermented food products with physiological relevance since its concentration is proportional to food spoilage and health risk for sensitive consumers.
Karen Rodríguez-Núñez, Alejandra Cortés-Monroy, Marcela Serey, Yunus Ensari, Mehdi D. Davari, Claudia Bernal, Ronny Martinez   +6 more
doaj   +1 more source

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]

, 2008
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Alban, Albini, Altmeyer, Bendtsen, Bhave, Chaponnier, Collard, Cunningham, Dosaka-Akita, Faivre, Ferlay, Goggins, Han, Holdenrieder, Jelski, Jelski, Jemal, Koya, Kulasingam, Kumar, Kuramitsu, Kwiatkowski, Kwiatkowski, Lee, Lundin, Martin, Martin Clynes, Michael Henry, Moreb, Naomi Walsh, Negm, Ni, Norma O'Donovan, Noske, Okano, Orchekowski, Paul Dowling, Paula Meleady, Safi, Sagawa, Shieh, Sladek, Tanaka, Tanaka, Tanudji, Tempero, Thompson, Thor, Wang, Winston, Yin, Yoshida   +51 more
core   +2 more sources

Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase? [PDF]

AMB Express, 2014
The Michael hydratase - alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a spectrophotometric assay and an activity staining in a ...
Resch, V.A. (author), Jin, J. (author), Chen, B.S. (author), Hanefeld, U. (author)   +3 more
openaire   +5 more sources

Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation

Nature Communications, 2015
A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the ...
T. Tan, D. Kracher, R. Gandini, C. Sygmund, R. Kittl, D. Haltrich, B. Martin Hällberg, R. Ludwig, C. Divne   +8 more
semanticscholar   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Enzymology of retinoic acid biosynthesis and degradation

Journal of Lipid Research, 2013
All-trans-retinoic acid is a biologically active derivative of vitamin A that regulates numerous physiological processes. The concentration of retinoic acid in the cells is tightly regulated, but the exact mechanisms responsible for this regulation are ...
Natalia Y. Kedishvili
doaj  

Impact of transgenic cottons expressing cry1Ac on soil biological attributes

Plant, Soil and Environment, 2013
Three transgenic Bt cotton hybrids (RCH-2 Bt, Bunny Bt and NHH 44 Bt) expressing cry1Ac gene were evaluated for their effects on soil biological, microbiological and diversity attributes at 0-15 cm and 15-30 cm soil depth under field conditions.
K. Velmourougane, A. Sahu
doaj   +1 more source