Results 41 to 50 of about 1,025,936 (342)
Diabetes & Metabolism Journal, 2018 Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex
Sungmi Park +6 more
semanticscholar +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Revista Ambiente & Água, 2010 Toxicity of oil refinery effluent on four bacteria strains isolated from refinery effluent impacted river water sample was assessed via dehydrogenase assay.
Gideon O. Abu +1 more
doaj +1 more source
Laboratory tests for aerobic bioremediation of the contaminated sites in the Czech Republic
Plant, Soil and Environment, 2020 Laboratory-scale testing methods applicable to evaluation of contaminated subsurface microbial communities are discussed in relation to their potential in supporting effective site bioremediation. Both culture-dependent and culture-independent techniques
Jana Chumchalová, Martin Kubal
doaj +1 more source
Foods, 2021 This study evaluated the effect of the combination of ultrasound and phenyllactic acid (PLA) on inactivating Staphylococcus aureus and Salmonella enteritidis biofilm cells and determined the possible antibiofilm mechanism. S. aureus and S.
Jiaojiao Zhang +6 more
doaj +1 more source
Nature Genetics, 2017 The mechanisms by which mitochondrial metabolism supports cancer anabolism remain unclear. Here, we found that genetic and pharmacological inactivation of pyruvate dehydrogenase A1 (PDHA1), a subunit of the pyruvate dehydrogenase complex (PDC), inhibits ...
Jingjing Chen +29 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Impact of canopy and seasoning on activity of soil enzymes in some Juniper habitatsof Iran [PDF]
تحقیقات جنگل و صنوبر ایران, 2010 Soil enzyme analysis is a widely used technique for examining nutrient cycling processes in soil. These enzymes are sensitive to the effects of anthropogenic activities and disturbance on the soil and provide valuable assessing of the metabolic response ...
Mohammad Matinizadeh +3 more
doaj