Results 51 to 60 of about 1,320,603 (414)
Isocitrate dehydrogenase mutations in myeloid malignancies
Leukemia, 2016 Alterations to genes involved in cellular metabolism and epigenetic regulation are implicated in the pathogenesis of myeloid malignancies. Recurring mutations in isocitrate dehydrogenase (IDH) genes are detected in approximately 20% of adult patients ...
B. Medeiros +5 more
semanticscholar +1 more source
FEMS Microbiology Letters, 1990 Formate is a substrate, or product, of diverse reactions catalyzed by eukaryotic organisms, eubacteria, and archaebacteria. A survey of metabolic groups reveals that formate is a common growth substrate, especially among the anaerobic eubacteria and archaebacteria.
openaire +2 more sources
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Proceedings of the National Academy of Sciences of the United States of America, 2010 As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hypoxia-inducible factor (HIF-1).
A. Le +9 more
semanticscholar +1 more source
Study on metabolic status of tear fluid in hypothyroidism patients with dry eye syndrome
Journal of Ophthalmology, 2018 Introduction. Dry eye syndrome (DES) is associated with a complicated multifactorial mechanism, the peculiarities of which are being studied at the moment.
M.I. Pavlovskii , G.I. Drozhzhyna
doaj +1 more source
Аграрная наука Евро-Северо-Востока, 2023 The paper presents data on a three-year study (2020-2022) of the effect of a liquid-phase biological product containing iron nanoparticles (LPB-Fe), obtained by biosynthesis using green tea extract, on the yield of potatoes of the Skarb variety and the ...
N. A. Lyubimova, G. Yu. Rabinovich
doaj +1 more source
Collaborative learning of images and geometrics for predicting isocitrate dehydrogenase status of glioma [PDF]
arXiv, 2022 The isocitrate dehydrogenase (IDH) gene mutation status is an important biomarker for glioma patients. The gold standard of IDH mutation detection requires tumour tissue obtained via invasive approaches and is usually expensive. Recent advancement in radiogenomics provides a non-invasive approach for predicting IDH mutation based on MRI.
arxiv
Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]
Electrophoresis 27 (04/2006) 1574-83, 2006 The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial rRNAs and a few tRNAs, we performed a comparative study on the 143B cell line and on its Rho-0 ...
arxiv +1 more source
Diabetes & Metabolism Journal, 2018 Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex
Sungmi Park +6 more
semanticscholar +1 more source
Folding of the Protein Domain hbSBD [PDF]
Biophysical J. 89, 3353 (2005), 2006 The folding of the alpha-helice domain hbSBD of the mammalian mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex is studied by the circular dichroism technique in absence of urea. Thermal denaturation is used to evaluate various thermodynamic parameters defining the equilibrium unfolding, which is well described by the two-state ...
arxiv +1 more source
Application of WST-8 based colorimetric NAD(P)H detection for quantitative dehydrogenase assays
BMC Biochemistry, 2019 BackgroundThe reduction of tetrazolium salts by NAD(P)H to formazan product has been widely used to determine the metabolic activity of cells, and as an indicator of cell viability.
Kamonwan Chamchoy +4 more
semanticscholar +1 more source