Results 61 to 70 of about 1,025,936 (342)

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

BMC Proceedings, 2012
Most tumors display enhanced glucose metabolism compared to normal tissues [1-6]. The preferential conversion of glucose to lactate in cancer cells (the Warburg Effect) was one of the first known differences between tumor and normal cells and is believed
J. Locasale, A. Grassian, R. Beroukhim, M. Meyerson, G. Wagner, J. Asara, J. Brugge, M. V. Vander Heiden, L. Cantley   +8 more
semanticscholar   +1 more source

Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase? [PDF]

AMB Express, 2014
The Michael hydratase - alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a spectrophotometric assay and an activity staining in a ...
Resch, V.A. (author), Jin, J. (author), Chen, B.S. (author), Hanefeld, U. (author)   +3 more
openaire   +5 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Impact of Bt-cotton on soil microbiological and biochemical attributes

Plant Production Science, 2016
Transgenic Bt-cotton produces Bt-toxins (Cry proteins) which may accumulate and persist in soil due to their binding ability on soil components. In the present study, the potential impacts of Bt- and non-Bt genotypes of cotton on soil microbial activity,
Sanaullah Yasin, Hafiz Naeem Asghar, Fiaz Ahmad, Zahir Ahmad Zahir, Ejaz Ahmad Waraich   +4 more
doaj   +1 more source

Selective enrichment of heterotrophic nitrifiers Alcaligenaceae and Alcanivorax spp. from industrial wastewaters

AIMS Microbiology, 2020
Removal of nitrogen from wastewaters (WW) represents a global problem. The low nitrification rate during WW treatment is often caused by ecotoxicity. This problem is attributed mostly to the industrial WW.
Mārtiņš Kalniņš, Andrejs Bērziņš, Dita Gudrā, Kaspars Megnis, Dāvids Fridmanis, Pavel Danilko, Olga Muter   +6 more
doaj   +1 more source

Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation

Nature Communications, 2015
A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the ...
T. Tan, D. Kracher, R. Gandini, C. Sygmund, R. Kittl, D. Haltrich, B. Martin Hällberg, R. Ludwig, C. Divne   +8 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Impact of transgenic cottons expressing cry1Ac on soil biological attributes

Plant, Soil and Environment, 2013
Three transgenic Bt cotton hybrids (RCH-2 Bt, Bunny Bt and NHH 44 Bt) expressing cry1Ac gene were evaluated for their effects on soil biological, microbiological and diversity attributes at 0-15 cm and 15-30 cm soil depth under field conditions.
K. Velmourougane, A. Sahu
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Influence of gap creation on soil enzymes activity in an oriental beech stand (Case study: Langa control plot) [PDF]

تحقیقات جنگل و صنوبر ایران, 2015
Gaps within forest canopy cause changes in the received amount (intensity) and quality (PAR) of incoming light on forest ground. This research was performed in natural gaps of a reserve control compartment at Kelardasht region in Mazandaran, northern ...
Samira Taati, Ramin Rahmani, Khosro Sagheb-Talebi, Mohammad Matinizadeh, Hashem Habashi   +4 more
doaj   +1 more source