Results 71 to 80 of about 1,224,293 (342)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Impact of Bt-cotton on soil microbiological and biochemical attributes

Plant Production Science, 2016
Transgenic Bt-cotton produces Bt-toxins (Cry proteins) which may accumulate and persist in soil due to their binding ability on soil components. In the present study, the potential impacts of Bt- and non-Bt genotypes of cotton on soil microbial activity,
Sanaullah Yasin, Hafiz Naeem Asghar, Fiaz Ahmad, Zahir Ahmad Zahir, Ejaz Ahmad Waraich   +4 more
doaj   +1 more source

Enzymatic activity of Phlebiopsis gigantea isolates

Acta Mycologica, 2013
Initial experiment was made in order to test wood-decomposing fungus Phlebiopsis gigantea for enzymatic activity. Laccase, peroxidase, cellulase, phosphatase, dehydrogenase were marked using different methods for P.
Anna Żółciak, Teresa A. Korniłłowicz-Kowalska, Zbigniew Sierota, Helena Iglik   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Impact of transgenic cottons expressing cry1Ac on soil biological attributes

Plant, Soil and Environment, 2013
Three transgenic Bt cotton hybrids (RCH-2 Bt, Bunny Bt and NHH 44 Bt) expressing cry1Ac gene were evaluated for their effects on soil biological, microbiological and diversity attributes at 0-15 cm and 15-30 cm soil depth under field conditions.
K. Velmourougane, A. Sahu
doaj   +1 more source

Transcriptional analysis of pqqD and study of the regulation of pyrroloquinoline quinone biosynthesis in Methylobacterium extorquens AM1 [PDF]

, 1995
Methanol dehydrogenase, the enzyme that oxidizes methanol to formaldehyde in gram-negative methylotrophs, contains the prosthetic group pyrroloquinoline quinone (PQQ).
Lidstrom, Mary E., Ramamoorthi, Roopa
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Effect of antiandrogen flutamide on measures of hepatic regeneration in rats [PDF]

, 1989
Male rat liver undergoes a process of demasculinization during hepatic regeneration following partial hepatectomy. The possibility that antiandrogens might potentiate this demasculinization process and in so doing augment the hepatic regenerative ...
A Francavilla, A Mode, A Schleusener, AE Pegg, AJ Syms, B Katchen, CL Mendenhall, CW Bardin, D Kahn, DM Cohen, E Bresnidk, E Mezey, E Mezey, E Mezey, EM Higgins, ER Lax, F Neumann, J Simard, J Terblanche, JA Gustafsson, JA Gustafsson, JA McGowan, JH Clark, JM Kissane, JP Blondeau, KE Crow, LE Porter, M Kayfman, M Sarff, MF Zuretti, OH Lowry, PK Eagon, PK Eagon, PK Eagon, R Neri, W Welshons, WJ King   +36 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A spatial analysis of physiological changes associated with infection of cotyledons of marrow plants with cucumber mosaic virus [PDF]

, 1996
Changes in host primary metabolism associated with the compatible interaction between cucumber mosaic virus and cotyledons of the marrow plant (Cucurbita pepo L.) have been localized, first by measuring activities of key enzymes in infected and ...
Leegood, R.C., Maule, A.J., Smith, A.M., Tecsi, L.I.   +3 more
core   +3 more sources