Results 81 to 90 of about 4,173,115 (343)
Incidence and management of patients with methotrexate delayed elimination in the clinical practice: A Delphi study [PDF]
, 2022 Luis Gros +11 more
openalex +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Eikonal phase matrix, deflection angle, and time delay in effective field theories of gravity [PDF]
, 2020 Manuel Accettulli Huber +3 more
openalex +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
2,5-Dimethyl-4-hydroxy-3(2H)-furanone (Furaneol®) from Methyl ?-D-Glucopyranoside
CHIMIA, 1992 An efficient synthesis of 2,5-dimethyl-4-hydroxy-3(2H)-furanone (Furaneol®), an important strawberry flavour, starting from the readily available and cheap methyl ?-D-glucopyranoside is described.
François Mazenod +2 more
doaj +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Particle impact location detector [PDF]
, 1974 Detector includes delay lines connected to each detector surface strip. When several particles strike different strips simultaneously, pulses generated by each strip are time delayed by certain intervals. Delay time for each strip is known.
Auer, S. O.
core +1 more source
Flocking estimates for the Cucker-Smale model with time lag and hierarchical leadership
, 2018 We analyze the Cucker-Smale model under hierarchical leadership in presence of a time delay. By using a Lyapunov functional approach and some induction arguments we will prove convergence to consensus for every positive delay $\tau$.
Pignotti, Cristina, Vallejo, Irene Reche
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source