Results 41 to 50 of about 50,137 (307)
Mathematics, 2022 Differential and integral equations in reflexive Banach spaces have gained great attention and hve been investigated in many studies and monographs. Inspired by those, we study the existence of the solution to a delay functional integral equation of ...
Ahmed M. A. El-Sayed, Yasmin M. Y. Omar
doaj +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Asymptotic Limits of the Solutions of Linear Systems of Functional-Differential Equations with Linear and Constant Delays [PDF]
, 2022 H. P. Pelyukh, D. V. Bel’skyi
openalex +1 more source
Parabolic differential equations with bounded delay
Journal of Evolution Equations, 2022 AbstractWe show the continuous dependence of solutions of linear nonautonomous second-order parabolic partial differential equations (PDEs) with bounded delay on coefficients and delay. The assumptions are very weak: only convergence in the weak-* topology of delay coefficients is required. The results are important in the applications of the theory of
Marek Kryspin, Janusz Mierczyński
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
On stability and boundedness of solutions of a certain fourth-order delay differential equation
International Journal of Mathematics and Mathematical Sciences, 1989 Using a Razumikhin - type theorem, we deduce sufficient conditions that guarantee the uniform asymptotic stability and boundedness of solutions of a scalar real fourth-order delay differential equation.
Emmanuel O. Okoronkwo
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Quintic B-Spline Technique for Numerical Treatment of Third Order Singular Perturbed Delay Differential Equation [PDF]
International Journal of Mathematical, Engineering and Management Sciences, 2019 In this paper, a class of third order singularly perturbed delay differential equation with large delay is considered for numerical treatment. The considered equation has discontinuous convection-diffusion coefficient and source term.
Mandeep Kaur Vaid, Geeta Arora
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source