Results 111 to 120 of about 38,967 (305)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Operational matrix based on Genocchi polynomials for solution of delay differential equations

open access: yesAin Shams Engineering Journal, 2018
In this paper, we present a new simple and effective algorithm for solving generalized Pantograph equations, delay differential equations with neutral terms and delay differential system with constant and variable coefficients.The new method is based on ...
Abdulnasir Isah, Chang Phang
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Mathematical models of health focusing on diabetes: Delay differential equations and data mining [PDF]

open access: yes
Mathematical models have been applied to biology and health to gain a better understanding of physiological systems and disease, as well as to improve levels of treatment and care for certain conditions.
Easton, Jonathan
core  

On exponential stability of second order delay differential equations [PDF]

open access: yes, 2015
summary:We propose a new method for studying stability of second order delay differential equations. Results we obtained are of the form: the exponential stability of ordinary differential equation implies the exponential stability of the corresponding ...
Maghakyan, Abraham   +2 more
core   +1 more source

Lp perturbations in delay differential equations

open access: yesElectronic Journal of Differential Equations, 2001
We present extensions and new proofs for the asymptotic formulae and theorems in Cooke [3] for differential equations with variable delay. Explicit asymptotic formulae, examples and comparisons with the classical results are given here.
Samuel Castillo, Manuel Pinto
doaj  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

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