Results 61 to 70 of about 264,840 (333)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Approximate analytical solutions and applications of pantograph-type equations with Caputo derivative and variable orders

Applied Mathematics in Science and Engineering, 2023
This study presents an efficient method that is suitable for differential equations, both with integer-order and fractional derivatives. This study examines the construction of solutions of fractional differential equations that are associated with ...
M.O. Aibinu, E. Momoniat
doaj   +1 more source

Synthesizing SystemC Code from Delay Hybrid CSP

, 2017
Delay is omnipresent in modern control systems, which can prompt oscillations and may cause deterioration of control performance, invalidate both stability and safety properties.
A Bellen, A Deshpande, A Girard, D Angeli, D Harel, E Ahmad, E Lee, G Pola, G Pola, G Yan, L Zou, M Anand, M Chen, M Fränzle, N Zhan, R Alur, TA Henzinger, Y Hur, Z Huang   +18 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A New Technique for Solving Neutral Delay Differential Equations Based on Euler Wavelets

Complexity, 2022
An effective numerical scheme based on Euler wavelets is proposed for numerically solving a class of neutral delay differential equations. The technique explores the numerical solution via Euler wavelet truncated series generated by a set of functions ...
Mutaz Mohammad, Alexander Trounev
doaj   +1 more source

Dichotomy results for delay differential equations with negative Schwarzian

, 2008
We gain further insight into the use of the Schwarzian derivative to obtain new results for a family of functional differential equations including the famous Wright's equation and the Mackey-Glass type delay differential equations.
an der Heiden, Collet, Diekmann, Eduardo Liz, Enciso, Gergely Röst, Gopalsamy, Gurney, Györi, Hadeler, Hale, Ivanov, Ivanov, Jones, Krisztin, Krisztin, Kuang, Lani-Wayda, Liz, Liz, Liz, Liz, Mackey, Mallet-Paret, Mallet-Paret, Mallet-Paret, Röst, Seifert, Singer, Smith, Stoffer, Walther, Walther, Wright, Xie   +34 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Asymptotic Stability of a Class of Impulsive Delay Differential Equations

Journal of Applied Mathematics, 2012
This paper is concerned with a class of linear impulsive delay differential equations. Asymptotic stability of analytic solutions of this kind of equations is studied by the property of delay differential equations without impulsive perturbations.
G. L. Zhang, M. H. Song, M. Z. Liu
doaj   +1 more source

Oscillatory behavior of even-order nonlinear differential equations with a sublinear neutral term [PDF]

Opuscula Mathematica, 2019
The authors present a new technique for the linearization of even-order nonlinear differential equations with a sublinear neutral term. They establish some new oscillation criteria via comparison with higher-order linear delay differential inequalities ...
John R. Graef, Said R. Grace, Ercan Tunç   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source