Results 61 to 70 of about 3,025,911 (286)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Approximate analytical solutions and applications of pantograph-type equations with Caputo derivative and variable orders

Applied Mathematics in Science and Engineering, 2023
This study presents an efficient method that is suitable for differential equations, both with integer-order and fractional derivatives. This study examines the construction of solutions of fractional differential equations that are associated with ...
M.O. Aibinu, E. Momoniat
doaj   +1 more source

Integral Operators and Delay Differential Equations [PDF]

Journal of Integral Equations and Applications, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gilsinn, David E., Potra, Florian A.
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Spectrum and Amplitude Equations for Scalar Delay-Differential Equations with Large Delay

, 2014
The subject of the paper is scalar delay-differential equations with large delay. Firstly, we describe the asymptotic properties of the spectrum of linear equations.
Serhiy Yanchuk, Matthias Wolfrum, Alexander Mielke, Leonhard Lücken, Lücken, Leonhard, Yanchuk, Serhiy, Mielke, Alexander, Wolfrum, Matthias   +7 more
core   +1 more source

Oscillatory behavior of even-order nonlinear differential equations with a sublinear neutral term [PDF]

Opuscula Mathematica, 2019
The authors present a new technique for the linearization of even-order nonlinear differential equations with a sublinear neutral term. They establish some new oscillation criteria via comparison with higher-order linear delay differential inequalities ...
John R. Graef, Said R. Grace, Ercan Tunç   +2 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Necessary and sufficient conditions for the oscillation of delay differential equation with a piecewise constant argument

International Journal of Mathematics and Mathematical Sciences, 1998
The characteristic equation for an equation with continuous and piecewise constant argument in the form x˙(t)+px(t−τ)+qx([t−k])=0    where  p, q∈ℜ, τ∈ℜ+and  k∈ℵ is presented, which when q=0 reduces to f(λ)=λ+e−λτ=0 and when p=0 reduces to λ−1+qλ−k=0 ...
H. A. Agwo
doaj   +1 more source

Existence Theorem for Impulsive Differential Equations with Measurable Right Side for Handling Delay Problems

Journal of Mathematics, 2020
Due to noncontinuous solution, impulsive differential equations with delay may have a measurable right side and not a continuous one. In order to support handling impulsive differential equations with delay like in other chapters of differential ...
Z. Lipcsey, J. A. Ugboh, I. M. Esuabana, I. O. Isaac   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source