Results 81 to 90 of about 264,840 (333)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Some Theorems of Uncertain Multiple-Delay Differential Equations

Axioms
Uncertain differential equations with a time delay, called uncertain-delay differential equations, have been successfully applied in feedback control systems.
Yin Gao, Han Tang
doaj   +1 more source

Analysis of stability for stochastic delay integro-differential equations

Journal of Inequalities and Applications, 2018
In this paper, we concern stability of numerical methods applied to stochastic delay integro-differential equations. For linear stochastic delay integro-differential equations, it is shown that the mean-square stability is derived by the split-step ...
Yu Zhang, Longsuo Li
doaj   +1 more source

Estimation of Solutions of Differential Systems with Delayed Argument of Neutral Type [PDF]

, 2012
Tato disertační práce pojednává o řešení diferenciálních rovnic a systémů diferenciálních rovnic. Hlavní pozornost je věnována asymptotickým vlastnostem rovnic se zpožděním a systémů rovnic se zpožděním.
Baštincová, Alena
core  

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Asymptotic Limits of the Solutions of Linear Systems of Functional-Differential Equations with Linear and Constant Delays [PDF]

, 2022
H. P. Pelyukh, D. V. Bel’skyi
openalex   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Necessary and sufficient conditions for the oscillation of delay differential equation with a piecewise constant argument

International Journal of Mathematics and Mathematical Sciences, 1998
The characteristic equation for an equation with continuous and piecewise constant argument in the form x˙(t)+px(t−τ)+qx([t−k])=0    where  p, q∈ℜ, τ∈ℜ+and  k∈ℵ is presented, which when q=0 reduces to f(λ)=λ+e−λτ=0 and when p=0 reduces to λ−1+qλ−k=0 ...
H. A. Agwo
doaj   +1 more source

$C^1$-smooth dependence on initial conditions and delay: spaces of initial histories of Sobolev type, and differentiability of translation in $L^p$

Electronic Journal of Qualitative Theory of Differential Equations, 2019
The objective of this paper is to clarify the relationship between the $C^1$-smooth dependence of solutions to delay differential equations (DDEs) on initial histories (i.e., initial conditions) and delay parameters. For this purpose, we consider a class
Junya Nishiguchi
doaj   +1 more source