Results 101 to 110 of about 23,229 (258)

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

The Return of the Allis Shad (Alosa alosa) to the Lower Navigable Reaches of the Seine: Locks Play a Role

River Research and Applications, EarlyView.
ABSTRACT In France, it is estimated that shads (Alosa spp.) have lost 69% of their historical range, mainly due to disrupted river connectivity. After an absence of one century, signs of their return in the Seine River have been recorded over the past two decades: adult and juvenile specimens have been caught by anglers or recorded at video‐counting ...
Céline Le Pichon, Frédérique Bau, Armand Michelot, Evelyne Tales, Sébastien Grall, Eric Rochard   +5 more
wiley   +1 more source

Driving Drugs Deeper: Force‐Driven Microneedle Systems for Active Therapy and Their Road Towards Clinical Implementation

Small, EarlyView.
Force‐driven microneedles are presented as active therapeutic microdevices that overcome the diffusion limits of conventional patches. By integrating gas generation, magnetic actuation, cavitation, or iontophoresis, these systems drive payloads deeper into tissue, enabling faster, more controlled delivery and highlighting key design principles and ...
Majed Amini, Phoebe Li, Hamed Shahsavan, Mahla Poudineh   +3 more
wiley   +1 more source

Kirigami‐Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery

Small, EarlyView.
We have engineered a kirigami‐inspired deployable microneedle robot (KiriBot) capable of remotely controlled attachment to target tissues for sustained drug release. KiriBot incorporates a flexible structure that enhances conformability, improves adherence to irregular tissues, and facilitates microneedle insertion.
Kun Zhou, Rujie Sun, Yuyang Zuo, David J. Peeler, Jonathan Yeow, Ruoxiao Xie, Junliang Lin, Yiming Ma, Yue Shao, Yuanxiong Cao, Zhengkun Chen, Molly M. Stevens   +11 more
wiley   +1 more source

When Time Stands Still: The Destructive Experience of Ambiguous Loss among Mothers of Combat Soldiers

Symbolic Interaction, EarlyView.
What happens when stories refuse coherence? This article examines ambiguous loss among mothers of combat soldiers, focusing on how prolonged waiting and uncertainty infiltrate everyday life, eroding sensemaking. Drawing on ethnographic interviews, it explores how mothers experience the contraction of time and space—manifested in suspended routines ...
Shirly Bar‐Lev, Galit Itzhaki Draizin, Agamit Gelb   +2 more
wiley   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source

Dysphagia in Children With Autism Spectrum Disorder: A Scoping Review

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective There are four phases of swallowing: oral preparatory, oral transit, oropharyngeal, and esophageal. Disruption of any phase(s) can lead to dysphagia. Autism spectrum disorder (ASD) children have a high rate of dysphagia compared with neurotypical peers.
Chase Hintelmann, Sharwani Kota, Pamela Hargwood, Lilun Li   +3 more
wiley   +1 more source

Short‐Term Surgical Outcomes of Palliative Gastrectomy According to the Extent of Lymph Node Dissection: A Nationwide Propensity Score–Weighted Cohort Analysis

World Journal of Surgery, EarlyView.
The appropriate extent of lymph node dissection (LND) during palliative gastrectomy (PALG) for stage IV gastric cancer remains undefined. This study evaluated short‐term surgical outcomes of limited versus extended LND in PALG. ABSTRACT Purpose The appropriate extent of lymph node dissection (LND) during palliative gastrectomy (PALG) for stage IV ...
Sang‐Ho Jeong, Rock Bum Kim, Miyeong Park, Kyung Won Seo, Jae‐Seok Min, Information Committee of the Korean Gastric Cancer Association   +5 more
wiley   +1 more source

A War of Words: Framing the Austrian Civil War through the Language of the Combatants

History, EarlyView.
Abstract The Austrian civil war was a four‐day conflict in 1934 between the largest left‐wing paramilitary, the Schutzbund, and government forces aligned with the largest right‐wing paramilitary group, the Heimwehr. The Schutzbund was quickly and brutally suppressed through the use of overwhelming force, armoured vehicles and even artillery deployment ...
Jenna Byers
wiley   +1 more source