Results 91 to 100 of about 38,575 (307)

Oxytocin prolongs the gastric emptying time in patients with diabetes mellitus and gastroparesis, but does not affect satiety or volume intake in patients with functional dyspepsia [PDF]

, 2012
Background: Oxytocin is released in response to a fatty meal. Blockage of the oxytocin receptor led to slower gastric emptying whereas stimulation resulted in less satiety in healthy volunteers.
Julia Borg, Bodil Ohlsson
core   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Laparoscopic gastric partitioning gastrojejunostomy for an unresectable duodenal malignant tumor

Journal of Minimal Access Surgery, 2005
As a palliative bypass for unresectable gastric or periampullary cancer, gastrojejunostomy (GJ) is sometimes associated with postoperative delayed gastric emptying.
Matsumoto Toshifumi, Izumi Koichi, Shiromizu Akio, Shibata Kohei, Ohta Masayuki, Kitano Seigo   +5 more
doaj  

Gastric Emptying of Low- and High-Caloric Liquid Meals Measured Using Ultrasonography in Healthy Volunteers

Ultrasound International Open, 2019
Purpose Delayed gastric emptying is present in patients with functional dyspepsia (FD), diabetes mellitus, and neurological diseases. Diet may affect gastric emptying symptoms in patients with FD.
Tarek Mazzawi, Emily Bartsch, Sara Benammi, Rosa Maria Carrasco Ferro, Ekaterina Nikitina, Nancy Nimer, Lara Jiménez Ortega, Charles Perrotte, Joäo Vitor Pithon, Safira Rosalina, Alexis Sharp, Reza Stevano, Jan Gunnar Hatlebakk, Trygve Hausken   +13 more
doaj   +1 more source

Mesenteric Vascular Dysregulation and Intestinal Inflammation Accompanies Experimental Spinal Cord Injury

, 2016
Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal-level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial ...
Besecker, Emily Swartz, Cooper, Timothy K., Deiter, Gina M., Holmes, Gregory Michael, Pironi, Nicole   +4 more
core   +1 more source

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]

, 2017
Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi, Cecilia Giulivi, Eleonora Napoli, Francesca Galuppini, Genny Orso, Ilaria Marsilio, Isabella Lante, Maria Cecilia Giron, Massimo Rugge, Mona Roozfarakh, Silvia Cerantola, Silvia Cerantola, Valentina Caputi   +12 more
core   +3 more sources

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Should Workers Avoid Consumption of Chilled Fluids in a Hot and Humid Climate?

Safety and Health at Work, 2017
Despite provision of drinking water as the most common method of occupational heat stress prevention, there remains confusion in hydration messaging to workers.
Matt B. Brearley
doaj   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula. [PDF]

, 2017
Oesophageal atresia and tracheoesophageal fistula (OA-TOF) are a multifaceted condition which affects patients throughout their lives. Even though it is one of the most common gastrointestinal malformations, most of the current studies focus on gastro ...
Duvoisin, G., Krishnan, U.
core   +1 more source