Results 91 to 100 of about 78,171 (296)

気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制

, 1992
Delayed cutaneous hypersensitivity towards Candida albicans was examined　in 200 patients with bronchial asthma in relation to patient age and the level of　total IgE. 1.
Tanizaki, Yosiro, Okazaki, Morihiro, Harada, Hideo, Kitani, Hikaru, Kimura, Ikuro, Ochi, Koji, Mitsunobu, Fumihiro, Mifune, Takashi   +7 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Delayed-Type hypersensitivity to latex: Computational prediction of MHC class II epitopes on latex allergens

, 2009
Delayed type hypersensitivity to natural rubber latex is rare compared to IgE mediated immediate reactions. Binding of allergens to MHC Class II is a crucial step in the presentation of antigens to CD4+ T Cells responsible for delayed reactions ...
Bell R. Eapen
core  

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Delayed Cutaneous Hypersensitivity Reaction to Carcinoembryonic Antigen in Cancer Patients

, 1982
The delayed cutaneous hypersensitivity reaction to carcinoembryonic antigen (CEA) was tested in 84 patients with different diseases including large bowel adenocarcinoma and breast carcinoma, with or without metastasis, liver cirrhosis and inflammatory ...
Giuseppe Fossati, Giuliano Bonfanti, Sergio Orefice, Enrico Pietrojusti   +3 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Drug Allergy: Delayed Cutaneous Hypersensitivity Reactions to Drugs

European Medical Journal Allergy & Immunology, 2016
Drug allergies, also termed adverse drug reactions (ADRs), are a problem for individuals of all ages, from paediatric to geriatric, and in all medical settings.
Rose L. Hamm
doaj  

Diagnosis of heparin-induced delayed type hypersensitivity

, 2010
SummaryHeparin is commonly used for prevention and therapy of thromboembolic diseases. Recently, work from a prospective epidemiological investigation has indicated, that heparin-induced skin lesions may be more frequent, than expected. Commonly, delayed-
R. J. Ludwig, M. Schindewolf, R. Kaufmann, B. Kahle, E. Lindhoff-Last, K. Hardt, M. Wolter, W.-H. Boehncke   +7 more
core   +1 more source

Cardiovascular Risk Assessment and Its Determinants Among Older Adults in India: Evidence From a Nationally Representative Survey

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Background Cardiovascular disease (CVD) is the leading cause of mortality, posing a major challenge to its rapidly aging demographic. Early identification of individuals at high risk for future cardiovascular events is paramount for implementing timely preventative strategies.
Vansh Maheshwari, Shyamashree Das, Saurav Basu   +2 more
wiley   +1 more source