Results 71 to 80 of about 2,728,579 (281)

The delayed hypersensitivity reaction in breast cancer

Journal of British Surgery, 1974
Abstract Women with breast cancer confined to the breast (stage I) have a reduced dermal delayed hypersensitivity reaction to Varidase; the degree of anergy to this antigen increases as the disease progresses. The in vitro reaction to phytohaemagglutinin, however, remains normal throughout the course of the disease.
M M, Roberts, W, Jones-Williams
openaire   +2 more sources

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

with delayed hypersensitivity to penicillins

, 2022
Nonimmediate (delayed)-allergic reactions to penicillins are common and some of them can be life-threatening. The genetic factors influencing these reactions are unknown/poorly known/poorly understood.
Pierre Rouyer, Rosa‐Maria Guéant‐Rodriguez, Gueant, Jean-Louis, Francesco Gaeta, Celine Chery, Oussalah, Abderrahim, Abderrahim Oussalah, Jose‐Antonio Cornejo‐Garcia, Thomas Josse, Jean‐Louis Guéant, Gueant-Rodriguez, Rosa-Maria, Gaeta, Francesco, Torres, Maria-Jose, Cristobalina Mayorga, Mayorga, Cristobalina, Romano, Antonino, Antonino Romano, Maria‐Jose Torres, Cornejo-Garcia, Jose-Antonio, Rouyer, Pierre, Josse, Thomas, Chery, Celine   +21 more
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

DELAYED HYPERSENSITIVITY AND HUMORAL IMMUNE RESPONSE IN STEERS EXPERIMENTALLY INFECTED WITH DIFFERENT STRAINS OF MYCOBACTERIA [PDF]

Veterinary Medical Journal - Giza, 1991
Animals infected with mycobacteria are allergic to the protein contained in PPD tuberculin and develop characteristic delayed type hypersensitivity react- ions when exposed to tuberculoproteins in tuberculin.
W.H. AWAD, R.A. DIMITRI, D.G. MIKHAIL, M.M. AMIN, S.N. GERGIS, H.E. SHAWKAT   +5 more
doaj   +1 more source

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Delayed-type of hypersensitivity reaction due to piperacillin/tazobactam causing severe thrombocytopenia

National Journal of Physiology, Pharmacy and Pharmacology, 2016
Piperacillin/tazobactam is a frequently prescribed and well-tolerated β-lactam antibiotic used in various clinical conditions with favorable side effect profile.
Mihir Parekh, Sanket Sheth, Bhalendu Vaishnav, Anusha Mangalampalli   +3 more
doaj   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

When antibiotics turn red: A case of piperacillin-tazobactam–induced baboon syndrome

Journal of Allergy and Clinical Immunology: Global
Symmetric drug-related intertriginous and flexural exanthema, also known as baboon syndrome, is a rare cutaneous adverse drug reaction that is classified as a delayed type IV hypersensitivity reaction mediated by T lymphocytes and characterized by a ...
Marta Bernaola, MD, Jaime Bernaola, MD, Patricia Majano, RN, Iciar Aldama, MD, Alvaro Alonso, RN, Ana Umpiérrez, MD   +5 more
doaj   +1 more source

Assessment of drug hypersensitivity with non-irritating concentrations of antibacterial agents for allergic skin tests: a review [PDF]

, 2014
Hypersensitivity reactions to antibiotics are common with a prevalence of 6-10% of all adverse reactions. There is a lack of guidelines and standardization of skin tests for the screening of hypersensitivity to all antibiotics, in terms of the ...
M. C., Shivamurthy, H. V., Anuradha, Biswas,Pritam   +2 more
core   +1 more source