Results 71 to 80 of about 133,978 (290)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Carga imediata em implantes dentários unitários [PDF]
, 2012 TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.O protocolo convencional com dois estágios cirúrgicos para a instalação de implantes osteointegrados revolucionou a forma de tratamento nos casos de ...
Cavichioni Junior, Jorge Manoel
core
Immediate Versus Delayed Loading of Postextraction Implants : a Long-Term Retrospective Cohort Study
, 2017 PURPOSE: To compare the long-term clinical and radiographic outcomes between immediate loading (IL) and conventional loading of implants placed immediately in fresh extraction sockets.
Massimo Del Fabbro +7 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Constitutive modelling of the behaviour of clays under cyclic loading
, 1989 Includes bibliography.This research work involved the implementation of a constitutive model based on plasticity theory to model the behaviour of a clay under cyclic loading.
Sellers, E J
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Modeling Delayed Flow Liquefaction Initiation after Cyclic Loading
, 2018 Ground shaking during earthquakes can be a prominent cause of strength loss in loose saturated soils. In some cases, uncontrolled pore pressure build-up and liquefaction may occur with a time lag with respect to strong ground motion, especially when the ...
Marinelli F., Buscarnera G., Shi Z.
core +1 more source
Discerning the Fatigue Crack Growth Behavior of API X65 Steels Under Sequence Loading
Latin American Journal of Solids and StructuresThis paper presents the effect of sequence loading on fatigue crack growth of API X65 steel tested in room temperature. Most of pipeline steels are subjected to wide spectrum of loading during the length of service.
N. I. I. Mansor +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source