Results 51 to 60 of about 463,166 (212)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]

, 2015
Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Barchi, Marco, DE ROOIJ, DIRK GIJSBERT, Di Cecca, Stefano, DI GIACOMO, Monica, DI SIENA, Sara, Faieta, Monica, Luchetti, Andrea, Murdocca, Michela, Pellegrini, Manuela, Rossi, Pellegrino   +9 more
core   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Repeated successful surgical rescues of early and delayed multiple ruptures of ventricular septum, right ventricle and aneurysmal left ventricle following massive biventricular infarction [PDF]

, 2006
A 58 year old man underwent 6 surgical interventions for various complications of massive biventricular myocardial infarction over a period of 2 years following acute occlusion of a possibly "hyperdominant" left anterior descending coronary artery. These
Pankaj Kaul, WM Daggett, GM Hutchin's, RG Cummings, JM Swithinbank, J Herlitz, JD Skehan, CA Moore, FF Cox, MJ Rearden, FW Sutherland, TE David, KD Hutchins, K Tanaka, G Schieman, V Mainar, W Blau, JC Madsen, JS Wang, BS Edwards, T Tashiro, T Hirotani, TE David, TE David, MJ Dalrymple-Hay, TA Barker, Gianantonio Nappi, F Musumeci, L Martinelli, N Tabuchi, D Reber, T Takahashi, LD Berrizbeitia, Y Bashir, Y Koh, M Massetti, JL Filiguiera, S Nagamine, C Barriuso, H Ohuchi, A Yamaguchi, MG Cardarelli, E Tatou, B Meyns, FR Waldenberger, SJ Park, C Faber, TE David, DA Killen, MA Deja, L Labrousse, DR Anderson, FF Cox, MJ Dalrymple-Hay, V Menon, B Vajifdar, P Pienvichit, JE Locke, R Anantharaman, R Holzer, WM Dagget, DD Muehrcke, G Mariscalio, JA Goldstein, EM Lee, R Frassani, MH Song, C Blanche, Y Sherer, JC Yuen, R Cartier, HC Suen, A Arbulu, A Kalangos, HC Suen, OY Abu, IN Nuno, JO Fulton, MTT Fukuoka, PE Sokolove, PM Kempen, T Dean, M Ono, KH Kharalambus, I Kusano, JS Tostes, SL Asplund, DD Glower, JG Grieco, JA de Oliveira, KJ Silverman, JC Davila, AS Olearchyk, MJ Anntunes, HD de Boer, AM Cherniavsky, C Guedon, NNGGMGF Luciani, A Kollaar, T Matsuyoshi, T Ivert, J Salas   +101 more
core   +2 more sources

EVALUATION OF LONG-TERM OUTCOMES FOR PENILE FRACTURES FOLLOWING IMMEDIATE VS. DELAYED SURGICAL REPAIR- A PROSPECTIVE STUDY.

Student's Journal of Health Research Africa, 2023
Purpose: A penile fracture may affect erectile dysfunction (ED) and overall sexual satisfaction. This study aimed to compare the long-term effects of immediate versus delayed surgical repair of penile fractures on postoperative ED, fibrous tunica ...
Sumanta Kumar Mishra, Sumit Kumar Panda, Jagat Ballav Jagdev, Pabitra Kumar   +3 more
doaj   +1 more source

Comparison of functional outcomes following early and delayed arthroscopic repair for traumatic and non-traumatic rotator cuff injuries

Journal of Orthopaedic Surgery and Research
Background The effects of the timing of surgical repair on the outcomes of traumatic and non-traumatic rotator cuff injuries (RCI) remain elusive.
Aixin Liu, Baorui Zhang, Tong Lai, Mingxing Wang, Gongyi Wu, Shilin Liu, Tao Zhang   +6 more
doaj   +1 more source

Traumatic lumbar hernias, when should I operate? A case report

International Journal of Abdominal Wall and Hernia Surgery, 2023
Traumatic lumbar hernias are a rare subset of abdominal wall hernias encountered following blunt trauma to the abdomen. These are more commonly being found due to the increased use of advanced imaging.
Fatima Alharmoodi, Shadin Ghabra, Ali Ahmad Chebli, Salem Alharthi, Shadi Al-Bahri   +4 more
doaj   +1 more source

DNMTs are required for delayed genome instability caused by radiation [PDF]

, 2012
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, RM, Armstrong, CA, Iyer, P, Jones, GD, Narayanan, D, Sandhu, J, Singh, R, Talbot, CJ, Talbot, CJ, Tufarelli, C, Tufarelli, C   +10 more
core   +2 more sources

Suppressor of gamma response 1 modulates the DNA damage response and oxidative stress response in leaves of cadmium-exposed Arabidopsis thaliana [PDF]

, 2020
Cadmium (Cd) exposure causes an oxidative challenge and inhibits cell cycle progression, ultimately impacting plant growth. Stress-induced effects on the cell cycle are often a consequence of activation of the DNA damage response (DDR).
Cuypers, Ann, De Veylder, Lieven, Eekhout, Thomas, Hendrix, Sophie, Horemans, Nele, Huybrechts, Michiel, Iven, Verena, Keunen, Els, Pecqueur, Ingeborg, Vangronsveld, Jaco   +9 more
core   +1 more source

Overexpression of PCNA Attenuates Oxidative Stress-Caused Delay of Gap-Filling during Repair of UV-Induced DNA Damage

Journal of Nucleic Acids, 2017
UVC irradiation-caused DNA lesions are repaired in mammalian cells solely by nucleotide excision repair (NER), which consists of sequential events including initial damage recognition, dual incision of damage site, gap-filling, and ligation.
Yi-Chih Tsai, Yi-Hsiang Wang, Yin-Chang Liu   +2 more
doaj   +1 more source