Results 71 to 80 of about 1,215,693 (290)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Flexor tend on injury of hand at zone II Early or delayed suture ?

مجلة كلية الطب, 2007
Background: The healing of a sutured tendon in the hand usually occur with an unwanted amount of scarring that defeat good results. Many variables has been studied over many decades; timing of repair M’as a matter of debate.
Mohammed A. Fadil Al bayatti, Medhat A. Alkafagi   +1 more
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Early versus delayed rehabilitation after arthroscopic rotator cuff repair [PDF]

, 2017
Objective: To determine how the timing of rehabilitation, early versus delayed, affects clinical results and tendon healing rates after arthroscopic rotator cuff repair. Design: Systematic literature review.
Dennis, Jessica, Chang, Abigail
core  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

A novel method of articular cartilage repair. [PDF]

, 2007
Articular cartilage repair of post-traumatic articular cartilage defects and well-defined articular cartilage pathology is challenging in clinical practice and has been the focus of investigations for many years.
Reissis, N., Reissis, Nikolaos
core  

DELAYED REPAIR OF A FRACTURED PENIS: A NEW TECHNIQUE

International Journal of Clinical Practice, 2003
SUMMARYFracture of the penis can be managed conservatively or surgically. Conservative management is associated with a high morbidity, and early surgical repair of the fracture is usually recommended in order to prevent complications. Because a fractured penis is swollen throughout its length, it is difficult to identify the fracture site accurately ...
V, Naraynsingh, M J, Ramdass, D, Thomas, D, Maharaj   +3 more
openaire   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cost-effectiveness of alternative methods of surgical repair of inguinal hernia [PDF]

, 2004
Objectives: To assess the relative cost-effectiveness of laparoscopic methods of inguinal hernia repair compared with open flat mesh and open non-mesh repair.
Aitola, P., Go, P., Bringman, S., Bay-Nielsen, M., Bittner, R., Payne, J., Vale, L., Merello, J., Castoro, C., O'Dwyer, P., Barkun, J., McCormack, K., Anderberg, B., Scott, N., Fingerhut, A., Grant, A., Kingsnorth, A., Ross, S., Beets, G., Arvidsson, D., et al.   +20 more
core   +1 more source

Treatment of a Subacute Locked Thumb Metacarpophalangeal Joint with Sesamoid Entrapment

Case Reports in Orthopedics, 2019
Introduction. Locked thumb metacarpophalangeal (MCP) joints due to entrapped radial sesamoids are rare injuries that commonly require open reduction, especially when the injury is delayed in presentation. Case Presentation. We present a case of a 24-year-
John J. Carroll, William D. McClain, Julia A. V. Nuelle   +2 more
doaj   +1 more source