Results 51 to 60 of about 467,316 (304)

Meier–Gorlin syndrome and Wolf–Hirschhorn syndrome: two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis [PDF]

, 2013
Microcephaly represents one of the most obvious clinical manifestations of impaired neurogenesis. Defects in the DNA damage response, in DNA repair, and structural abnormalities in centrosomes, centrioles and the spindle microtubule network have all been
Abramowicz, Iga, Carpenter, Gillian, Colnaghi, Rita, Kerzendorfer, Claudia, O'Driscoll, Mark   +4 more
core   +1 more source

Rare Complications of Cervical Spine Surgery: Pseudomeningocoele. [PDF]

, 2017
STUDY DESIGN: This study was a retrospective, multicenter cohort study. OBJECTIVES: Rare complications of cervical spine surgery are inherently difficult to investigate.
Ailon, Tamir, Arnold, Paul M., Buser, Zorica, Chou, Dean, Corriveau, Mark, Fehlings, Michael G., Fish, David E., Hilibrand, Alan S., Hsu, Wellington K., Lee, Sungho, Lord, Elizabeth L L., Massicotte, Eric M., Mroz, Thomas E., Mummaneni, Praveen V., Nassr, Ahmad, Pace, Jonathan, Riew, K. Daniel, Sasso, Rick C., Sebastian, Arjun S., Shaffrey, Christopher, Smith, Gabriel A., Smith, Justin S., Smith, Zachary A., Steinmetz, Michael P., Than, Khoi D., Traynelis, Vincent C., Wang, Jeffrey C.   +26 more
core   +2 more sources

The Arabidopsis thaliana checkpoint kinase WEE1 protects against premature vascular differentiation during replication stress [PDF]

, 2011
A sessile lifestyle forces plants to respond promptly to factors that affect their genomic integrity. Therefore, plants have developed checkpoint mechanisms to arrest cell cycle progression upon the occurrence of DNA stress, allowing the DNA to be ...
Cools, Toon, Iantcheva, Anelia, Weimer, Annika K, Boens, Shannah, Takahashi, Naoki, Maes, Sara, Van Den Daele, Hilde, Van Isterdael, Gert, Schnittger, Arp, De Veylder, Lieven   +9 more
core   +2 more sources

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Comparison of Outcome Between Early and Delayed Repair of Flexor Tendons

Pakistan Armed Forces Medical Journal
Objective: To determine the association of functional outcome for flexor tendon repair for the surgery timings. Study Design: Case Series. Place and Duration of Study: Plastic and Reconstructive Surgery Department, Dr Ruth KM Pfau Civil Hospital ...
Aiman Naseem, Faisal Akhlaq Ali, Hyder Ali, Usamah bin Waheed, Mehak Ali, Saima Tasleem   +5 more
doaj   +1 more source

Delayed external sphincter repair for obstetric tear

Journal of British Surgery, 1988
Abstract In some patients with faecal incontinence due to an obstetric tear of the external anal sphincter there is additional weakness of the anal sphincter muscles from damage to the innervation of these muscles during delivery. Of 19 patients who required surgical repair of an obstetric sphincter tear some months or years after injury,
S, Laurberg, M, Swash, M M, Henry
openaire   +2 more sources

Nerve Transfer in Delayed Obstetrical Palsy Repair [PDF]

Journal of Brachial Plexus and Peripheral Nerve Injury, 2015
 When root avulsions are detected in children suffering from obstetrical brachial plexus palsy (OBPP), neurotization procedures of different nerve trunks are commonly applied in primary brachial plexus repair, to connect distally the nerves of the upper limbs using healthy nerve structures.
Filippo, Sénès, Nunzio, Catena, Jacopo, Sénès   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Abdominal intercostal hernia: a rare complication after blunt trauma. [PDF]

, 2013
Abdominal intercostal hernia (AIH) is uncommonly reported in the literature with only 20 cases reported to date.1–3 We report a case of a delayed incarcerated AIH secondary to blunt trauma from a motor vehicle accident in which the colon and diaphragm ...
Cowan, MD, Scott W., Jenoff, MD, Jay S., Nguyen, B.A., Phi D, Pucci, MD, Michael J.   +3 more
core   +1 more source