Results 91 to 100 of about 741,169 (252)

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Management of hemodynamically unstable pelvic fracture in pregnancy: a case report and review of literature

Chinese Journal of Traumatology, 2012
【Abstract】 We present an unusual case of an un-stable pelvic fracture during pregnancy period, who suf-fered fetal death and splenic rupture simultaneously which developed massive delayed hemorrhage in abdomen.
ZHANG Peng, ZHOU Dong-sheng, HU Jing-mei, LI Lian-xin, MU Wei-dong   +4 more
doaj  

Grade IV splenic injury: When to consult interventional radiology-a case report and review of management protocols

International Journal of Gastrointestinal Intervention
The spleen is one of the organs most commonly affected by blunt abdominal trauma. Splenectomy is often indicated for high-grade post-traumatic injuries and in patients who are hemodynamically unstable, while non-operative management (NOM) is considered ...
Madhukar Dayal, Pratik Pandey, Abhay Kumar   +2 more
doaj   +1 more source

Non-Operative Management of Delayed Splenic Rupture 4 Months Following Blunt Abdominal Trauma. [PDF]

Am J Case Rep, 2021
Kofinas AG, Stavrati KE, Symeonidis NG, Pavlidis ET, Psarras KK, Shulga IN, Marneri AG, Nikolaidou CC, Pavlidis TE.   +8 more
europepmc   +1 more source

Spontaneous rupture of splenic hemangioma in puerperium

, 2012
"\"\\\"Atraumatic splenic rupture is a rare clinical entity and in the absence of trauma, the diagnosis and treatment are often delayed. In this article the authors discuss a case of a 45-year-old woman, gravida 5, para 4, with spontaneous splenic ...
Franchi V, CARTA, Gaspare, PALERMO, PATRIZIA, D'ALFONSO, ANGELA, Nallbani A, PATACCHIOLA, FELICE   +5 more
core  

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Incidental intraoperative discovery of a pancreatic neuroendocrine tumor associated with chronic pancreatitis

Diagnostic Pathology, 2012
Pancreatic neuroendocrine tumors are a rare entity with an incidence between 2 per million to 5 per 100 000. Association with pancreatitis (acute or chronic) is rare and is considered to be determined by the tumoral obstruction of pancreatic ducts, but ...
Surlin Valeriu, Ramboiu Sandu, Ghilusi Mirela, Plesea Iancu   +3 more
doaj   +1 more source

A case of splenic torsion and rupture presenting as ruptured ectopic pregnancy

, 2010
Splenic torsion with rupture of spleen is an extremely rare phenomenon. The clinical picture mimics several common conditions which are causes of acute abdomen and so it is seldom detected pre-operatively.
Somdatta Lahiri, Nabanita Dasgupta, Aftab-ud-din Mondal   +2 more
core