Results 141 to 150 of about 1,095,316 (316)

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Malaysian Journal Of Islamic Studies (MJIS)
Abstract This paper examines the role of legitimate state policies in regulating and stabilizing the Omani market through an applied and analytical study spanning the years 2019 to 2024. It investigates how Sharia-based intervention tools influence the equilibrium of supply and demand in the goods and services market, highlighting their contribution to
null Khaloud Hamoud Hamed Al Arimi, null Amer Abdulwahab Mahyoub Murshed, null Osman Md Rasip   +2 more
openaire   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A defect in early myogenesis causes Otitis media in two mouse models of 22q11.2 Deletion Syndrome

, 2014
Otitis media (OM), the inflammation of the middle ear, is the most common disease and cause for surgery in infants worldwide. Chronic Otitis media with effusion (OME) often leads to conductive hearing loss and is a common feature of a number of ...
Fuchs, JC, Baldini, A, Linden, JF, Tucker, AS   +3 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

DLL1 haploinsufficiency in prenatal brain anomalies: a retrospective analysis of 6q terminal deletions

Frontiers in Genetics
Objective6q terminal deletion is a rare genetic cause of prenatal brain anomalies. We evaluated five cases of cerebral dysplasia within a familial context for genetic diagnosis.
Tingting Ge, Tingting Ge, Xiaojuan Lin, Xiaojuan Lin, Xinyuan Tian, Xiaoyu Song, Xiaoyu Song, Bingbo Zhou, Ling Hui, Xiaozhuan Wang, Xiaozhuan Wang, Zhiqiang Zhang, Chuan Zhang   +12 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Emergence and Pathogenicity of a Novel PRRSV-1 Strain GD18-2 in Southern China

Animals
The detection rate of Porcine Reproductive and Respiratory Syndrome Virus type 1 (PRRSV-1) in China has been increasing, with its growing genetic diversity and evolving pathogenicity posing significant challenges to disease control.
Feibao Huang, Hui Guo, Yi Song, Yuanyuan Fu, Guangrun Qin, Limiao Lin, Haishen Zhao, Bohua Ren, Qunhui Li, Yu Wu, Zezhong Zheng   +10 more
doaj   +1 more source

Frequency of the mitochondrial DNA 4977bp deletion in oesophageal mucosa during the progression of Barrett’s oesophagus

, 2009
Purpose: The mechanisms of the progression of Barrett’s oesophagus (BO) to oesophageal adenocarcinoma (OA) are poorly understood. The frequency of the 4977bp deletion in mitochondrialDNA (mtDNA) was investigated in specimens ranging from normal ...
Gilmour, Hugh, Fearon, Kenneth, De Beaux, Andrew, Paterson-Brown, Simon, Skipworth, Richard, Stephens, Nathan, Wheelhouse, Nicholas, Tan, Benjamin, Ross, James   +8 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source