Results 141 to 150 of about 1,098,495 (316)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Large copy number variants are an important cause of congenital hyperinsulinism that should be screened for during routine testing

Frontiers in Endocrinology
IntroductionCongenital hyperinsulinism (HI) is characterized by inappropriate insulin secretion from the pancreatic beta-cells which causes severe hypoglycemia.
Sarah E. Flanagan, Isabella-Anna Lazaridi, Jonna M. E. Männistö, Jonna M. E. Männistö, Jasmin J. Bennett, Oguzhan Kalyon, Matthew B. Johnson, Matthew N. Wakeling, Jayne A. L. Houghton, Thomas W. Laver   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

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Malaysian Journal Of Islamic Studies (MJIS)
Abstract This paper examines the role of legitimate state policies in regulating and stabilizing the Omani market through an applied and analytical study spanning the years 2019 to 2024. It investigates how Sharia-based intervention tools influence the equilibrium of supply and demand in the goods and services market, highlighting their contribution to
null Khaloud Hamoud Hamed Al Arimi, null Amer Abdulwahab Mahyoub Murshed, null Osman Md Rasip   +2 more
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Alternative surgical methods for ptosis in patients with 18p deletion syndrome [PDF]

, 2017
Sang Beom HanDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, South KoreaWe read the article by Xu et al1 entitled “A case of 18p deletion syndrome after ...
Han SB
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, Volume 16, Issue 8, Page 1509-1526, August 2026.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Absence of biallelic TCR? deletion predicts induction failure and poorer outcomes in childhood T-cell acute lymphoblastic leukemia [PDF]

, 2014
Background The absence of biallelic TCR? deletion (ABD) is a characteristic of early thymocyte precursors before V(D)J recombination. The ABD was reported to predict early treatment failure in T-cell acute lymphoblastic leukemia (ALL).
林東燦 ;俞松良 ;周獻堂 ;林淑華 ;盧孟佑 ;張修豪 ;林凱信 ;楊永立, Yang, Yung-Li;Hsiao, Chih-Cheng;Chen, Hsuan-Yu;Lin, Kai-Hsin;Jou, Shiann-Tarng;Chen, Jiann-Shiuh;Chang, Te-Kau;Sheen, Jiunn-Ming;Yu, Sung-Liang;Lu, Meng-Yao;Cheng, Chao-Neng;Wu, Kang-Hsi;Wang, Shih-Chung;Wang, Jiaan-Der;Chang, Hsiu-Hao;Lin, Shu-Rung;Lin, Shu-Wha;Lin, Dong-Tsamn   +1 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, Volume 16, Issue 8, Page 1537-1549, August 2026.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source