Results 101 to 110 of about 332,049 (298)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The Results of Deliberation [PDF]

, 2016
When evaluating whether to sue, prosecute, settle, or plead, trial lawyers must predict the future—they need to estimate how likely they are to win a given case in a given jurisdiction.
Wittlin, Maggie
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Learning to integrate reactivity and deliberation in uncertain planning and scheduling problems [PDF]

This paper describes an approach to planning and scheduling in uncertain domains. In this approach, a system divides a task on a goal by goal basis into reactive and deliberative components. Initially, a task is handled entirely reactively. When failures
Chien, Steve A., Dejong, Gerald F., Gervasio, Melinda T.   +2 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Power and Citizen Deliberation: The Contingent Impacts of Interests, Ideology, and Status Differences

Journal of Deliberative Democracy, 2019
Both advocates and critics of deliberative theory have regarded power relations as problems for public deliberation. Three aspects—interests, ideology and status differences—have been thought to distort deliberative processes.
Markus Holdo
doaj   +2 more sources

Deliberate Disability [PDF]

BMJ, 1956
J R, HAWKINGS, K S, JONES, M, SIM, R W, TIBBETTS   +3 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Acting without considering personal costs signals trustworthiness in helpers but not punishers

Communications Psychology
Third-party punishment and helping can signal trustworthiness, but the interpretation of deliberation may vary: uncalculated help signals trustworthiness, but this may not hold for punishment.
Nicole C. Engeler, Nichola J. Raihani
doaj   +1 more source

Recent Work on Internal and External Reasons [PDF]

, 2017
This paper examines some recent arguments for internalism that (i) appeal to an analogy between practical and theoretical reasons, (ii) look toward our practices of reasoning with others, or (iii) tie reasons to good deliberation.
Brunero, John
core