Results 111 to 120 of about 332,049 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Democracy and Deliberation: Two Models of Public Justification [PDF]

open access: yes, 2013
El compromiso con la necesidad de ofrecer una “justificación adecuada” de las decisiones políticas vinculantes que sea aceptada o resulte aceptable para todos los ciudadanos afectados, constituye uno de los rasgos distintivos de la idea de deliberación ...
Garreta Leclercq, Mariano Raul
core  

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

INFLUENCIA DE LA CONCEPCIÓN DELIBERATIVA DE LA DEMOCRACIA EN EL PROCEDIMIENTO LEGISLATIVO COLOMBIANO [PDF]

open access: yesRatio Juris, 2014
Given that the decision making in legislative matter and of constitu- tional reform in Colombia is exercised by a representative body, the Congress - , and also citizen participation mechanisms that serve to promote or control the work of that organ are ...
Andrés Díaz del Castillo
doaj  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

The Legal Institutionalisation of Public Deliberation and the Embeddedness in the Democratic System: The Italian Case

open access: yesPolitics and Governance
Over the last few decades, the setting up of deliberative processes has gained prominence in many democratic countries. These processes, which can be considered as small parentheses in longer and complex policy-making processes, are designed and managed ...
Stefania Ravazzi
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Concilier mini-public délibératif et représentation élue dans l’élaboration de la loi : la perception de la Convention citoyenne pour le climat par les députés français

open access: yesLien Social et Politiques
La Convention citoyenne pour le climat (CCC) a permis à 150 citoyens tirés au sort d’élaborer un ensemble de propositions visant à réduire l’impact climatique de la France.
Aurélia Friès-Flaubert
doaj   +1 more source

Tax Salience, Voting, and Deliberation [PDF]

open access: yes
Tax incentives can be more or less salient, i.e. noticeable or cognitively easy to process. Our hypothesis is that taxes on consumers are more salient to consumers than equivalent taxes on sellers because consumers underestimate the extent of tax ...
Jean-Robert Tyran, Rupert Sausgruber
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

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