Results 141 to 150 of about 63,663 (310)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Applications of Public Deliberation: Themes Emerging fromTwelve Personal Experiences Emanating from National Issues Forums Training

open access: yes, 2007
In order to learn about post-training efforts in public deliberation in Oklahoma, a study was conducted with individuals who had completed a two-day course to become conveners, moderators, and recorders of deliberative forums. In Phase Two of the study (
Williams, Sue E., Daugherty, Renée A.
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Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito   +8 more
wiley   +1 more source

Review of Governing Biodiversity through Democratic Deliberation by Mikko Rask and Richard Worthington (New York: Routledge, 2015.)

open access: yes, 2015
Review of Governing Biodiversity through Democratic Deliberation by Mikko Rask and Richard Worthington (New York: Routledge, 2015.
Fiske, Desirée A.
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Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay   +13 more
wiley   +1 more source

New Ideas on Public Deliberation from Young Scholars. Introduction: Innovations in Deliberative Electoral Designs

open access: yes, 2013
In this introduction, we discuss the importance of innovation in advancing deliberative democratic theory and practice. Prior examples reviewed include the Citizens’ Jury, the Deliberative Poll, the British Columbia Citizens’ Assembly, and particularly ...
Gastil, John, Richards, Robert C, Jr
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Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Review of Deliberation, Democracy, and Civic Forums: Improving Equality and Publicity by Christopher F. Karpowitz and Chad Raphael (New York, NY: Cambridge University Press, 2014).

open access: yes, 2015
Review of Deliberation, Democracy, and Civic Forums: Improving Equality and Publicity by Christopher F. Karpowitz and Chad Raphael (New York, NY: Cambridge University Press, 2014)
McKerrow, Raymie E
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Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes   +75 more
wiley   +1 more source

Identifying Deliberation in Social Movement Assemblies: Challenges of Comparative Participant Observation

open access: yes, 2008
Contemporary social movements can serve as a critical case for the empirical study of deliberation. In countless face-to-face meetings activists often discuss long hours before a decision is reached.
Haug, Christoph, Teune, Simon
core  

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