Results 81 to 90 of about 1,802,515 (269)
FORMULATION STRATEGIES FOR ENHANCED TOPICAL BIOAVAILABILITY
Разработка и регистрация лекарственных средств, 2019 This article has described some of the ways in which the delivery of an active ingredients, in terms of there rate of permeation and location within the skin, can be controlled through formulation design. Every ingredient in the formulation possesses the
W. Small
doaj
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
Prevalence and risk factors associated with preterm births in Neyshabur hospitals, Eastern Iran [PDF]
Journal of Research Development in Nursing and MidwiferyBackground: The increasing prevalence of preterm birth in many societies has raised concerns. This study was conducted to determine the prevalence and risk factors associated with preterm birth in hospitals in Neyshabur, Eastern Iran. Methods: This cross-
Mehrdad Rohaninasab +3 more
doaj
Molecular Therapy: Nucleic Acids, 2018 In recent years, synthetic mRNA-based applications to produce desired exogenous proteins in cells have been gaining importance. However, systemic delivery of synthetic mRNA can result in unspecific uptake into undesired cells or organs and, thereby, fail
Sonia Golombek +8 more
doaj +1 more source
Delivery and Delivery Frequency
Bulletin of Science and PracticeVaginal delivery is preferred given that morbidity and mortality associated with operative caesarean section have increased over time. Caesarean section is a unique measure of preserving the health and life of the mother or fetus, but the global rise in its frequency is alarming. Medical caesarean section is an effective method of reducing maternal and
openaire +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source