Results 101 to 110 of about 1,159,279 (350)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

2.2 kW Single-Mode Narrow-Linewidth Laser Delivery Through a Hollow-Core Fiber [PDF]

, 2023
Max Cooper, Joseph Wahlen, Stephanos Yerolatsitis, José Enrique Antonio-Lopez, Daniel Delgado, Daniel Parra, Ben Tanner, O.C. Jones, Ivan Divliansky, Axel Schülzgen, Rodrigo Amezcua Correa   +10 more
openalex   +1 more source

Supporting the attainment of professional attributes in a work based learning programme [PDF]

, 2012
With the impending change in the higher education landscape within the UK there is a greater need for flexibility and innovation in the delivery of degree programmes.
Penlington, Roger, Perera, Noel
core  

Effectiveness of interventions to promote physical activity among socioeconomically disadvantaged women : a systematic review and meta-analysis

, 2013
Physical activity is important for preventing weight gain and obesity, but women experiencing socioeconomic disadvantage are at high risk of inactivity. This study aimed to determine the effectiveness of interventions to increase physical activity among ...
Abraham, Albright, Andajani-Sutjahjo, Ball, Ball, Baranowski, Baranowski, Brown, Chang, Chenoweth, Chinn, Cleland, Cleland, Cleland, Cleland, Cleland, Cliska, Conn, Courneya, Cyarto, Dobbins, Eakin, Eyler, Fahrenwald, Fjeldsoe, Giles-Corti, Glanz, Haskell, Hovell, Isreal, Jacobi, Jacobs, Kahn, Katzmarzyk, Kavanagh, King, Liberati, Lucumi, Lupton, Lupton, Marcus, Marshall, Moher, Napolitano, Olvera, Opdenacker, Orrow, Pan, Pate, Salmon, Salmon, Scarborough, Shirazi, Sluijs, Speck, Spurrier, Stoddard, Taylor, Thomas, Trost, US Department of Health and Human Services, Wang, Watson, Welch, Wen, Wendel-Vos, Wilcox, Williams, Withall, Wolinsky, World Health Organization, World Health Organization, Yancey   +72 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

AN INVESTIGATIONAL RESEARCH ON THE CORRELATION BETWEEN THE MANAGER‘S ROLE IN TRAINING PROGRAMS AND TRAINING TRANSFER IN A LOCAL GOVERNMENT OFFICE IN MALAYSIA [PDF]

This research was designed to investigate the correlation between manager‘s role andtraining transfer. A survey method was employed to gather 427 usable questionnaires fromgovernment servants in a local government office in Malaysia.
Ali Fazilatulaili, Hamid Norashikin Sahol, Hua Ng Kueh, Ismail Azman   +3 more
core  

Fuel delivery system including heat exchanger means [PDF]

, 1978
A fuel delivery system is presented wherein first and second heat exchanger means are each adapted to provide the transfer of heat between the fuel and a second fluid such as lubricating oil associated with the gas turbine engine.
Coffinberry, G. A.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source